concept

CSNK1A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CSNK1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

166Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CSNK1A1 is a concept in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Als, Autoimmune. Connected to 79 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CSNK1A1
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AND, APC
Related Diseases	Als, ALS, Alzheimer, Autoimmune, Autoimmunity
Related Pathways	Amyloid, Autophagy

Pathway Diagram

graph TD
    CSNK1A1["CSNK1A1"]
    CSNK1A1 -->|"inhibits"| STING1["STING1"]
    CSNK1A1 -->|"activates"| Als["Als"]
    CSNK1A1 -->|"activates"| Tumor["Tumor"]
    CSNK1A1 -->|"activates"| Autoimmune["Autoimmune"]
    CSNK1A1 -->|"activates"| Carcinoma["Carcinoma"]
    CSNK1A1 -->|"activates"| ALS["ALS"]
    CSNK1A1 -->|"activates"| SQSTM1["SQSTM1"]
    SSTC3["SSTC3"] -->|"activates"| CSNK1A1
    P62["P62"] -->|"activates"| CSNK1A1
    SQSTM1 -->|"activates"| CSNK1A1
    CGAS["CGAS"] -->|"activates"| CSNK1A1
    GENES["GENES"] -->|"activates"| CSNK1A1
    PIK3C3["PIK3C3"] -->|"activates"| CSNK1A1
    RUBCN["RUBCN"] -->|"activates"| CSNK1A1
    SMURF1["SMURF1"] -->|"regulates"| CSNK1A1
    UVRAG["UVRAG"] -->|"regulates"| CSNK1A1
    STING1 -->|"activates"| CSNK1A1

Outgoing (98)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CSNK1A1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
SQSTM1	phosphorylates	entity	0.90
Autophagic Degradation	associated_with	process	0.90
STING1	phosphorylates	protein	0.85
STING	interacts_with	entity	0.85
Autoimmunity	protects_against	disease	0.85
STING1	inhibits	gene	0.72
autophagy pathway	participates_in	pathway	0.70
Carcinoma	activates	disease	0.65
Als	regulates	disease	0.65
ALS	activates	disease	0.65
Tumor	activates	disease	0.65
Hepatocellular Carcinoma	activates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Ms	regulates	disease	0.65
Autoimmune	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	activates	disease	0.65
SQSTM1	activates	gene	0.64
STING1	interacts_with	gene	0.64
MAP1LC3	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
CYCLIN D1	associated_with	gene	0.60
RAS	associated_with	gene	0.60
AXIN	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
IFN	regulates	gene	0.60
Cgas-Sting	activates	pathway	0.60
Amyloid	regulates	pathway	0.60
Lipid Metabolism	regulates	pathway	0.60
SQSTM1	associated_with	gene	0.60
RNA	associated_with	gene	0.60
FAM83A	associated_with	gene	0.60
AND	activates	gene	0.60
CANCER	associated_with	gene	0.60
CCND1	associated_with	gene	0.60
ATG	associated_with	gene	0.60
TSPAN1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
MIR454	associated_with	gene	0.60
CGAS	activates	gene	0.60
cancer	activates	disease	0.60
GAPDH	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
APC	associated_with	gene	0.60

Incoming (68)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CSNK1A1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
P62	activates	gene	0.70
SSTC3	activates	drug	0.64
GLIOBLASTOMA	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
CANCER	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
FURIN	regulates	gene	0.60
GENES	regulates	gene	0.60
BACE1	regulates	gene	0.60
IFN	regulates	gene	0.60
RAB7A	associated_with	gene	0.60
TCF4	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
AXIN	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
APC	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
RAS	associated_with	gene	0.60
GFP	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
GSK3B	associated_with	gene	0.60
MTORC1	activates	gene	0.60
BECN1	activates	gene	0.60
AND	regulates	gene	0.60
AND	activates	gene	0.60
CTNNB1	associated_with	gene	0.60
SQSTM1	activates	gene	0.60
CGAS	activates	gene	0.60
GENES	activates	gene	0.60
PIK3C3	activates	gene	0.60
RUBCN	activates	gene	0.60
SMURF1	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
MICROGLIA	regulates	gene	0.60
GBM	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
WNT	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
UVRAG	regulates	gene	0.60
MYC	associated_with	gene	0.60
LC3	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
AXIN2	associated_with	gene	0.60
ATG	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
STING1	activates	gene	0.60
SQSTM1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CSNK1A1 in their description or question text

No additional research found