gene

VPS35

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS35: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

428Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

1Experiments

4Debates

Summary

Gene profile: VPS35 — retromer complex component linked to PARK17 Parkinson's disease

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	VPS35
Full Name	Vacuolar Protein Sorting 35 Homolog
Aliases	Vacuolar Protein Sorting 35
Protein Type	Protein
Function	Cargo Recognition: Binds to transmembrane cargo proteins containing cytoplasmic sorting motifs
Molecular Weight	91.6 kDa
Amino Acids	796 aa
Pathways	Wnt
UniProt ID	Search UniProt
GeneCards	VPS35
Human Protein Atlas	VPS35
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Interactions	ABCA1, ABCA7, AD, AMYLOID, AND, APP
SciDEX Hypotheses	VPS35 retromer activation prevents endosomal tau t VPS35 Retromer Dysfunction Creates a GCase Traffic
KG Connections	427 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: VPS35 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VPS35["VPS35"]
    VPS35 -->|"causes"| PD["PD"]
    VPS35 -->|"contributes to"| Parkinson["Parkinson"]
    VPS35 -->|"contributes to"| Als["Als"]
    VPS35 -->|"contributes to"| Inflammation["Inflammation"]
    VPS35 -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
    VPS35 -->|"contributes to"| Ms["Ms"]
    VPS35 -->|"target for"| Aging["Aging"]
    PARK7["PARK7"] -->|"contributes to"| VPS35
    PINK1["PINK1"] -->|"contributes to"| VPS35
    GBA1["GBA1"] -->|"contributes to"| VPS35
    SNCA["SNCA"] -->|"contributes to"| VPS35
    LRRK2["LRRK2"] -->|"contributes to"| VPS35
    PRKN["PRKN"] -->|"contributes to"| VPS35
    AGING["AGING"] -->|"target for"| VPS35
    FLAVONOIDS["FLAVONOIDS"] -->|"target for"| VPS35
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| VPS35
    DRP1["DRP1"] -->|"interacts"| VPS35

Outgoing (190)

Target	Relation	Type	Str
Parkinson's Disease	causes	disease	0.95
Parkinson's disease	associated_with	disease	0.95
Parkinson's Disease	associated_with	disease	0.95
Retromer Complex	component_of	pathway	0.95
Retinal Degeneration	contributes_to	phenotype	0.95
Late Endosomal Trafficking	regulates	process	0.95
TAU	regulates	protein	0.95
Retromer-Dependent Endosomal Trafficking	involved_in	process	0.95
p.D620N mutation	causes	mechanism	0.95
TRPL	regulates	protein	0.90
APLP1	regulates	protein	0.90
Endo-Lysosome System	regulates	organelle	0.90
CHL1	regulates	protein	0.90
PINK1/parkin-mediated mitophagy	inhibits	pathway	0.90
Presynaptic Trafficking	regulates	process	0.90
Alzheimer's Disease	associated_with	disease	0.90
Α-SYNUCLEIN	associated_with	protein	0.90
HSC70	interacts_with	protein	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Inflammatory Cell Death	regulates	process	0.85
TAU PROTEIN	regulates	protein	0.85
DAT	interacts_with	protein	0.85
MAPL-Induced Pyroptosis	regulates	process	0.85
LRRK2	associated_with	protein	0.85
Protein Transport	mediates	process	0.85
LRRK2 kinase activity	upregulates	mechanism	0.85
GLUA1	regulates	receptor	0.85
Amyloid Precursor Protein Cleavage	regulates	process	0.85
SYNAPTIC GLUTAMATE RECEPTORS	regulates	receptor	0.85
Phosphorylated Tau	downregulates	entity	0.85
Microglial Phenotype	regulates	phenotype	0.80
Ubiquitin-Proteasome System	regulates	process	0.80
Mapl-Induced Pyroptosis	regulates	process	0.80
autophagy pathway	participates_in	pathway	0.80
Parkinson'S Disease	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
PD	causes	disease	0.72
BST-2	regulates	protein	0.70
GLUTAMATE	transports	phenotype	0.65
AUTOPHAGY	treats	phenotype	0.65
NEURONS	regulates	cell_type	0.65
ALS	activates	disease	0.65
Ms	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	contributes_to	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Parkinson	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (238)

Source	Relation	Type	Str
entities-snx5	associated_with	wiki	0.00
SYNJ1	interacts_with	gene	0.95
FAF2	interacts_with	entity	0.85
LDLR	activates	gene	0.70
TFEB	interacts_with	gene	0.70
MACROPHAGE	inhibits	cell_type	0.70
NEURONS	activates	cell_type	0.70
NRF2	activates	gene	0.70
PSEN1	activates	gene	0.70
SQSTM1	activates	gene	0.70
LAMP1	activates	gene	0.70
TAU	activates	gene	0.70
STING	associated_with	gene	0.70
DOPAMINERGIC	associated_with	cell_type	0.70
FBXO7	targets	gene	0.70
APP	mediates	gene	0.70
PICALM	associated_with	gene	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
NEURON	degrades	cell_type	0.65
LRRK2	regulates	gene	0.65
NMDA	interacts_with	gene	0.60
NEURON	activates	cell_type	0.60
MITOPHAGY	regulates	gene	0.60
PARKINSON'S DISEASE	causes	disease	0.60
NEURON	causes	cell_type	0.60
ABCA1	enhances	gene	0.60
CD2AP	enhances	gene	0.60
LDLR	enhances	gene	0.60
PICALM	enhances	gene	0.60
TREM2	degrades	gene	0.60
TREM2	activates	gene	0.60
AD	interacts_with	gene	0.60
TREM2	interacts_with	gene	0.60
AD	regulates	gene	0.60
MICROGLIA	regulates	cell_type	0.60
TREM2	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	disease	0.60
PARKINSON'S DISEASE	regulates	disease	0.60
PARK7	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
DJ1	associated_with	gene	0.60
PD	co_discussed	gene	0.60
MTDNA	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
GENES	activates	gene	0.60
DNA	therapeutic_target	gene	0.60
SNCA	inhibits	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VPS35 retromer activation prevents endosomal tau templating	0.740	neurodegeneration	Which tau propagation mechanism predomin
VPS35 Retromer Dysfunction Creates a GCase Trafficking Bottl	0.700	neurodegeneration	-
VPS35 Retromer Restoration to Rescue Endosomal Protein Traff	0.525	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (2)

Scientific analyses that reference this entity

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 16 hypotheses Top: 0.591

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.453

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Evidence regarding pain in VPS35 pathogenic variants is limited and in	genetic_association	Parkinson's disease	0.500	0.00	human	extracted	N/A

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405]	Li S, Yan Z, Zhi X, Zheng W, Zhang Z et	Bioact Mater	2026
Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939]	Wan D, Qi Y, Kang Y, Liang F, Wang Q et	RSC Med Chem	2026
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026
VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560]	Lee S, Park S, Bang H, Kim SU, Park YH e	Genes (Basel)	2026
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663]	Song P, Chen C, Franchini R, Duong B, Wa	J Clin Invest	2026
The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708]	Buneeva OA, Medvedev AE	Biomed Khim	2026
Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978]	Deng IB, Bu M, Follett J, Sharp R, Mamai	bioRxiv	2026
Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440]	Santinelli L, Pratuseviciute N, Lange LM	Mov Disord	2026

Debates (4)

Multi-agent debates referencing this entity

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

closed · Rounds: 4 · Score: 0.68 · 2026-04-14

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

closed · Rounds: 4 · Score: 0.62 · 2026-04-14

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

closed · Rounds: 4 · Score: 0.92 · 2026-04-14

Related Research

Hypotheses and analyses mentioning VPS35 in their description or question text

No additional research found

VPS35

Understanding Entity Pages

Summary

Wiki Pages (12)

VPS35 — Vacuolar Protein Sorting 35 Homolog

VPS35 Retromer Dysfunction Parkinson's Disease Causal Chain

VPS35 Retromer Stabilizer for Lysosomal Rescue

VPS35/Retromer Pathway in Parkinson's Disease

VPS35 Protein

VPS35 Pathway in Parkinson's Disease

VPS35/Retromer Stabilizers for Parkinson's Disease

VPS35 Retromer Pharmacological Chaperone

VPS35/Retromer Stabilizers for Parkinson's Disease

VPS35 Retromer Targeting Therapies

VPS35 Mutant Neurons

VPS35 Protein

Pathway Diagram

Outgoing (190)

Incoming (238)

Targeting Hypotheses (3)

Mentioning Analyses (2)

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

Experiments (1)

Related Papers (8)

Debates (4)

How does synaptic protein turnover change with age and neurodegeneration, and wh

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

The abstract shows microglia ameliorate OxPC toxicity to neurons and oligodendro

Related Research