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mechanism 1,616 words KG: ent-gene-a90f5952
Contents

VPS35/Retromer Stabilizers for Parkinson's Disease

🔬 Protein Info
Gene Symbolent-gene-a90f5952
Function- AMPA receptor subunits: Synaptic plasticity
VPS35Large subunit, scaffold for complex assembly
VPS26Small subunit, cargo recognition
VPS29Adaptor subunit, coordinates function
AMPA receptor subunitsSynaptic plasticity
IGF1 receptorCell survival signaling
APPAmyloid precursor protein processing
Sialidase Neu1Lysosomal function
GPI-attached proteinsVarious neuronal functions
KG Connections7 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

Wikipedia

Related Hypotheses (4)

Membrane Cholesterol Gradient Modulators
Score: 0.71Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72APOE-Dependent Autophagy Restoration
Score: 0.88TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69

Related Analyses (30)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedSynaptic pruning by microglia in early AD
neurodegeneration · archivedTREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45AAV Serotype Comparison for LRRK2 Knockdown in PD
validation · proposed · Score: 0.40Alpha-Synuclein SAA Kinetics Study — Biological Staging Back
clinical · proposed · Score: 0.40Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40

Knowledge Graph (7 edges)

38368930 encodes core component of ent-gene-a90f5952
38368930 encodes ent-gene-a90f5952
38368930 encodes a core component essential for ent-gene-a90f5952
h-9bcba57f3f targets ent-gene-a90f5952
ent-gene-a90f5952 targeted_by h-9bcba57f3f
ent-gene-a90f5952 data_in benchmark_ot_ad_answer_key:VPS35
benchmark_ot_ad_answer_key:VPS35 data_in ent-gene-a90f5952

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