gene 2,886 words KG: VPS35
Contents

VPS35 — Vacuolar Protein Sorting 35 Homolog

🧬 Gene Info
Gene SymbolVPS35
Full NameVacuolar Protein Sorting 35 Homolog
AliasesVacuolar Protein Sorting 35
Protein TypeProtein
FunctionCargo Recognition: Binds to transmembrane cargo proteins containing cytoplasmic sorting motifs
Molecular Weight91.6 kDa
Amino Acids796 aa
PathwaysWnt
UniProt IDSearch UniProt
GeneCardsVPS35
Human Protein AtlasVPS35
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
InteractionsABCA1, ABCA7, AD, AMYLOID, AND, APP
SciDEX HypothesesVPS35 retromer activation prevents endosomal tau t
KG Connections428 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (24)

TREM2-Dependent Microglial Senescence Transition
Score: 0.95
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78

Related Analyses (11)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (14)

ABCA7 (Redirect)
redirect · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: regulates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: associated_with
ATG5 — Autophagy Related 5
gene · KG edge: regulates

Knowledge Graph (12 edges)

VPS35 associated_with PARKIN
VPS35 associated_with DJ1
VPS35 associated_with VPS13D
VPS35 associated_with GBA
VPS35 associated_with VPS11
VPS35 associated_with PIK3C3
LRRK2 co_discussed VPS35
PARK7 co_discussed VPS35
PINK1 co_discussed VPS35
PRKN co_discussed VPS35

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