mechanism

Retromer Complex

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Retromer Complex: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

11Outgoing

6Incoming

0Experiments

0Debates

Summary

The retromer complex is a highly conserved multi-protein assembly that mediates the retrograde transport of transmembrane proteins from endosomes back to the trans-Golgi network (TGN) or the plasma membrane. In the central nervous system, retromer dysfunction has emerged as a convergent pathogenic m

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⚙ Mechanism Info

Name	Retromer Complex
Key Genes/Proteins	RAB7A, VPS35

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Retromer Complex

mechanism · 1629 words

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Retromer Complex Neurons

cell · 750 words

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Pathway Diagram

flowchart TD
    Retromer_Complex{{"Retromer Complex"}}
    Protein_Trafficking("Protein Trafficking")
    Retromer_Complex -->|"involved in"| Protein_Trafficking
    Endolysosomal_System("Endolysosomal System")
    Retromer_Complex -->|"regulates"| Endolysosomal_System
    Receptor_Recycling("Receptor Recycling")
    Retromer_Complex -->|"mediates"| Receptor_Recycling
    VPS35(["VPS35"])
    VPS35 -->|"component of"| Retromer_Complex
    RAB7A(["RAB7A"])
    RAB7A -->|"interacts with"| Retromer_Complex
    Tau_Pathobiology("Tau Pathobiology")
    Retromer_Complex -->|"involved in"| Tau_Pathobiology

    style Retromer_Complex fill:#4a148c,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (11)

Target	Relation	Type	Str
Protein Trafficking	involved_in	process	0.95
Endolysosomal System	regulates	organelle	0.95
Receptor Recycling	mediates	process	0.95
Endosomal Protein Sorting	mediates	process	0.95
Protein Trafficking	regulates	process	0.95
Endosomal Trafficking	mediates	process	0.95
endosomal recycling	mediates	process	0.85
mitophagosome formation	involved_in	process	0.85
Tau Pathobiology	involved_in	process	0.80
DAT	mediates	protein	0.80
RAB7A	interacts_with	protein	0.80

Incoming (6)

Source	Relation	Type	Str
VPS35	component_of	protein	0.95
VPS26A	component_of	protein	0.95
VPS29	component_of	protein	0.95
VPU	interacts_with	protein	0.90
RAB7A	interacts_with	protein	0.85
SORL1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity