gene

CHL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

5Outgoing

9Incoming

0Experiments

0Debates

Summary

Page for CHL1 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CHL1
Full Name	CHL1 Neural Cell Adhesion Molecule
Chromosome	3p26.3
Function	encodes a neural cell adhesion molecule belonging to the L1 family of immunoglobulin superfamily CAMs.
Primary Expression	the nervous system:
Molecular Weight	200 kDa
Amino Acids	209 aa
UniProt ID	P0CAT4
NCBI Gene ID	10752
Ensembl ID	ENSG00000113838
OMIM	300114
GeneCards	CHL1
Human Protein Atlas	CHL1
Extracellular domain	Contains 6 Ig-like domains and 5 fibronectin type III repeats, mediating homophilic and heterophilic interactions
Transmembrane domain	Single pass transmembrane region
Associated Diseases	neurodegeneration
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHL1 — AlphaFold P0CAT4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHL1["CHL1"]
    Alzheimer{"Alzheimer"}
    CHL1 -->|"therapeutic target"| Alzheimer
    Als{"Als"}
    CHL1 -->|"therapeutic target"| Als
    Ms{"Ms"}
    CHL1 -->|"therapeutic target"| Ms
    neurodegeneration["neurodegeneration"]
    CHL1 -->|"implicated in"| neurodegeneration
    TIMP1["TIMP1"]
    TIMP1 -->|"associated with"| CHL1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| CHL1
    GATA2["GATA2"]
    GATA2 -->|"therapeutic target"| CHL1
    PDGFRB["PDGFRB"]
    PDGFRB -->|"associated with"| CHL1
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"therapeutic target"| CHL1
    style CHL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Alzheimer's Disease	correlates_with	disease	0.85
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
epilepsy	targets	disease	0.55

Incoming (9)

Source	Relation	Type	Str
VPS35	regulates	protein	0.90
APP	mediates	protein	0.75
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
IMMUNE INFILTRATION	therapeutic_target	gene	0.60
TIMP1	associated_with	gene	0.60
GATA2	therapeutic_target	gene	0.60
PDGFRB	associated_with	gene	0.60
BACE1	targets	gene	0.55
BACE1	co_mentioned	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

CHL1

Understanding Entity Pages

Summary

Wiki Pages (7)

CHL1 Gene

UCHL1 (PARK5) Pathway in Parkinson's Disease

CHL1 Protein

UCHL1 Ubiquitin-Proteasome Parkinson's Disease Causal Chain

UCHL1 Gene

UCHL1 Ubiquitin C-terminal Hydrolase Neurons

UCHL1 Protein