| Gene Symbol | VPS35 |
| Aliases | Vacuolar Protein Sorting 35 |
| Protein Type | Protein |
| Function | Cargo Recognition: Binds to transmembrane cargo proteins containing cytoplasmic sorting motifs |
| Molecular Weight | 91.6 kDa |
| Amino Acids | 796 aa |
| Pathways | Wnt |
| UniProt ID | Search UniProt |
| GeneCards | VPS35 |
| Human Protein Atlas | VPS35 |
| N-terminal beta-propeller domain | Mediates interaction with VPS26 |
| C-terminal alpha-helical domain | Binds to cargo recognition proteins |
| Cargo-binding interface | Recognizes sorting motifs (e.g., NPxY, YxxΦ) |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis |
| Interactions | ABCA1, ABCA7, AD, AMYLOID, AND, APP |
| SciDEX Hypotheses | VPS35 retromer activation prevents endosomal tau t VPS35 Retromer Dysfunction Creates a GCase Traffic |
| KG Connections | 427 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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