Contents

VPS35 Retromer Stabilizer for Lysosomal Rescue

🔬 Protein Info

Gene Symbol	ent-gene-a90f5952
Primary Expression	Ubiquitous; critical in neurons due to extreme endosomal trafficking demand (synaptic vesicle recycling, receptor sorting)
Subcellular Localization	Endosomal membrane; cycles between early endosomes, recycling endosomes, and trans-Golgi network
Primary Target	VPS35-VPS29 interface of the retromer cargo-selective complex
Target Type	Pharmacological chaperone / protein-protein interaction stabilizer
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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