Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microglial Phenotype: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Brain Injury Progression | contributes_to | process | 0.85 |
| Immune Regulation Of Nervous System | mediates | process | 0.82 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Brain Lipid Profiles | modulates | biomarker | 0.90 |
| TREM2-APOE pathway | modulates | pathway | 0.90 |
| CNS-infiltrating macrophages | associated_with | cell_type | 0.85 |
| VPS35 | regulates | protein | 0.80 |
| PLCG2 | modulates | protein | 0.70 |
| MEF2C | modulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Targeted Butyrate Supplementation for Microglial Phenotype M | 0.700 | neurodegeneration | What are the mechanisms by which gut mic |
| Dynamic Microglial Phenotype Switching Biomarker Panel for N | 0.577 | neurodegeneration | What amyloid threshold level is required |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.629
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| GPR109A receptor validation using knockout macrophages | exploratory | Mycoplasma pneumoniae pneumoni | 0.920 | 0.00 | GPR109A knockout mouse macroph | proposed | N/A |
| Periodontitis-induced colonic inflammation in mice | validation | Periodontitis and intestinal i | 0.900 | 0.00 | C57BL/6J mice | proposed | N/A |
| Fecal microbiota transplantation from periodontitis donors | validation | Periodontitis-associated gut d | 0.900 | 0.00 | Germ-free mice with fecal micr | proposed | N/A |
| GPR109A functional modulation with pharmacological agents | validation | Periodontitis with intestinal | 0.880 | 0.00 | C57BL/6J mice with ligature-in | proposed | N/A |
| Probiotic CBM588 supplementation rescue experiment | validation | Periodontitis-associated intes | 0.850 | 0.00 | C57BL/6J mice with periodontit | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| GPR109a-AMPK axis mediates the Attenuation of uric acid-induced M1 macrophage po [PMID:41882026] | Du M, He Y, Zhu Y, Chen W, Chen X, Yang | Scientific reports | 2026 | 0 |
| Gut microbiota-derived isovaleric acid alleviates atrial fibrillation by suppres [PMID:41638192] | Ding N, Wu H, Hua Y, Hua R, Li B, Xie Y, | Cell metabolism | 2026 | 0 |
| Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840] | Tortelote GG | Pediatr Nephrol | 2026 | 0 |
| Xin-Jia-Tong-Xie-Yao-Fang restores the intestinal barrier to alleviate irritable [PMID:41655800] | Zhu J, Yang L, Fang Z, Chen J, Fu R, Liu | Microbial pathogenesis | 2026 | 0 |
| Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408] | Cattero V, Mayer T, Veilleux A, Roussel | Scientific reports | 2026 | 0 |
| Qingfei Tongluo Jiedu Formula Regulates M2 Macrophage Polarization via the Butyr [PMID:41754753] | Liu Z, Fan Q, Sun R, Jiang Y | Pharmaceuticals (Basel, Switze | 2026 | 0 |
| Periodontitis promotes intestinal inflammation through gut microbiota-mediated s [PMID:41816355] | Wang X, Xu Z, Yao Y, Jia H, Du M, Wang S | Frontiers in cellular and infe | 2026 | 0 |
| Hydroxycarboxylic acid receptor 2 (GPR109A) and retinopathies: pathways and pros [PMID:41889514] | Lester J, Amamoo R, Thounaojam MC, Marti | Frontiers in medicine | 2026 | 0 |
| Exercise-induced β-hydroxybutyrate contributes to cognitive improvement in aging [PMID:41421649] | Wang L, Mao L, Zhu D, Li K, Gao H, Zhou | Journal of sport and health sc | 2025 | 0 |
| Chaperone-mediated autophagy, heat shock protein 70, and serotonin: novel target [PMID:40319428] | ["Mohamed R", "Abdallah D", "El-Abhar H" | Inflammopharmacology | 2025 | 0 |
| Not Just an Alternative Energy Source: Diverse Biological Functions of Ketone Bo [PMID:40305364] | Suresh VV, Sivaprakasam S, Bhutia YD, Pr | Biomolecules | 2025 | 0 |
| β-Hydroxybutyrate Regulates Activated Microglia to Alleviate Neurodegenerative P [PMID:36771231] | Jayashankar SS, Tajul Arifin K, Nasarudd | Nutrients | 2023 | 0 |
| Bacterial factors required for Streptococcus pneumoniae coinfection with influen [PMID:34452635] | Chen YY, Huang CT, Li SW, Pan YJ, Lin TL | Journal of biomedical science | 2021 | 0 |
| Face masks considerably reduce COVID-19 cases in Germany. [PMID:33273115] | Mitze T, Kosfeld R, Rode J, Wälde K | Proceedings of the National Ac | 2020 | 0 |
| Serum neuronal exosomes predict and differentiate Parkinson's disease from atypi [PMID:32273329] | Jiang C, Hopfner F, Katsikoudi A, Hein R | Journal of neurology, neurosur | 2020 | 0 |
| Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions. [PMID:33028628] | Luhur A, Mariyappa D, Klueg KM, Buddika | G3 (Bethesda, Md.) | 2020 | 0 |
| Massive Hemoptysis and Recurrent Infective Endocarditis in Intravenous Drug user [PMID:33154920] | Almutairi MD, El-Ghoneimy YA, Alghamdi A | Journal of the Saudi Heart Ass | 2020 | 0 |
| Surgical approach to a left-sided gallbladder. [PMID:31420438] | Pereira R, Perera M, Roberts M, Avramovi | BMJ case reports | 2019 | 0 |
| Comparison of tension band wiring and other tibial tuberosity advancement techni [PMID:31578143] | McCartney W, Ober C, Benito M, MacDonald | Acta veterinaria Scandinavica | 2019 | 0 |
| Predictive Role of High Blood Pressure for the Incidence of Metabolic Syndrome. [PMID:31261156] | Presta V, Miceli F, Tocci G | Cardiology | 2019 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
Hypotheses and analyses mentioning Microglial Phenotype in their description or question text
No additional research found