gene

ABCG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

247Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ABCG1
Full Name	ATP-Binding Cassette Subfamily G Member 1
Chromosome	21q22.3
Protein Type	Transporter
Function	is a critical lipid transporter protein that plays a fundamental role in cellular cholesterol and phospholipid homeostasis.
Primary Expression	neurons, astrocytes, microglia, and oligodendrocytes, where it regulates brain lipid homeostasis and protects against neurodegeneration[@tansley2007][
Molecular Weight	67 kDa
Exons	23
Pathways	Cholesterol
UniProt ID	P45878
NCBI Gene ID	26273
Ensembl ID	ENSG00000160179
OMIM	603076
GeneCards	ABCG1
Human Protein Atlas	ABCG1
Associated Diseases	AD, Als, Alzheimer, AMI, ARM
Known Drugs/Compounds	quercetin
Interactions	4E-BP1, ABCA1, ABCA7, ACTB, Actin, AKT
KG Connections	247 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ABCG1 — AlphaFold P45878 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ABCG1 Gene

gene · 2366 words

→

ABCG1 Protein

protein · 943 words

→

Pathway Diagram

graph TD
    ABCG1["ABCG1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ABCG1["ABCG1"] -.->|"inhibits"| Mtor["Mtor"]
    ABCG1["ABCG1"] -->|"interacts"| ATP["ATP"]
    ABCG1["ABCG1"] -.->|"inhibits"| MTOR["MTOR"]
    ABCG1["ABCG1"] -->|"interacts"| Als["Als"]
    ABCG1["ABCG1"] -->|"activates"| Atherosclerosis_1["Atherosclerosis"]
    ACTB["ACTB"] -->|"interacts"| ABCG1["ABCG1"]
    P2RY12["P2RY12"] -.->|"inhibits"| ABCG1["ABCG1"]
    APOA1["APOA1"] -->|"interacts"| ABCG1["ABCG1"]
    ULK1["ULK1"] -->|"interacts"| ABCG1["ABCG1"]
    style ABCG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (182)

Target	Relation	Type	Str
R-HSA-1369062	member_of	pathway	1.00
R-HSA-8964058	member_of	pathway	1.00
R-HSA-9029569	member_of	pathway	1.00
Cholesterol Efflux	mediates	process	0.85
Atherosclerosis	inhibits	disease	0.75
Mtor	inhibits	pathway	0.70
MTOR	inhibits	gene	0.70
APOE	treats	gene	0.70
ATP	interacts_with	gene	0.70
APOE	associated_with	gene	0.70
Atherosclerosis	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
ALS	inhibits	disease	0.65
Carcinoma	expressed_in	disease	0.65
cholesterol homeostasis	participates_in	pathway	0.65
Cancer	expressed_in	disease	0.65
Als	regulates	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Atherosclerosis	activates	disease	0.65
ALS	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Tumor	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
Dna Methylation	associated_with	pathway	0.60
P2RY12	inhibits	gene	0.60
LC3	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
AKT	activates	gene	0.60
RORA	expressed_in	gene	0.60
TGM2	expressed_in	gene	0.60
PIK3R1	expressed_in	gene	0.60
HMGB1	activates	gene	0.60
TNF	activates	gene	0.60
DHCR24	associated_with	gene	0.60
Actin	interacts_with	protein	0.60
DNA	associated_with	gene	0.60
App	associated_with	protein	0.60
Raf	regulates	protein	0.60
Ras	regulates	protein	0.60
epigenetic regulation	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
LDLR	associated_with	gene	0.60
ABCA1	inhibits	gene	0.60
HMGB1	inhibits	gene	0.60

Incoming (65)

Source	Relation	Type	Str
genes-abcg1	describes	wiki_page	0.95
AMPK	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
LDL	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
MAO	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
LOX	interacts_with	gene	0.60
AKT	inhibits	gene	0.60
SQSTM1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
ABCG4	regulates	gene	0.60
PARP1	inhibits	gene	0.60
ABCA1	expressed_in	gene	0.60
ABCA7	expressed_in	gene	0.60
ABCA7	activates	gene	0.60
ABCA7	regulates	gene	0.60
quercetin	targets	drug	0.60
AUTOPHAGY	interacts_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
AND	interacts_with	gene	0.60
ATP	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
GENES	associated_with	gene	0.60
APOE Ε4	associated_with	gene	0.60
ABCA2	expressed_in	gene	0.60
ATP7A	expressed_in	gene	0.60
ARG1	interacts_with	gene	0.60
ABCA1	activates	entity	0.60
ABCA1	inhibits	gene	0.60
APOE	associated_with	gene	0.60
DHCR24	associated_with	gene	0.60
ACTB	interacts_with	gene	0.60
P2RY12	inhibits	gene	0.60
APOA1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
EIF4EBP1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
ABCD3	expressed_in	gene	0.60
PI3K	regulates	gene	0.60
DNA	associated_with	gene	0.60
APOE	inhibits	gene	0.60
PLIN1	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
APOE	regulates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4 astrocytes exhibit impaired cholesterol efflux via ABC	0.760	neuroscience	APOE4-driven lipid metabolism dysregulat
Selective LXRβ agonists restore ABCA1/ABCG1 expression and A	0.710	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The expanding world of neuroscience. [PMID:39423798]	Unknown	Cell	2024
Neuroscience: Past and Future. [PMID:29621483]	Unknown	Neuron	2018
Neurolaw and Neuroethics. [PMID:30720413]	Unknown	Camb Q Healthc Ethics	2018
Applied neuroscience. [PMID:25247360]	Unknown	Curr Biol	2014
Neuroscience in recession? [PMID:21505517]	Unknown	Nat Rev Neurosci	2011

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ABCG1 in their description or question text

No additional research found