gene

DHCR24

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DHCR24: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

110Connections

0Hypotheses

0Analyses

50Outgoing

43Incoming

0Experiments

0Debates

Summary

DHCR24 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in, associated with. Associated with AD, ALS, AMI. Connected to 72 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DHCR24
Full Name	24-Dehydrocholesterol Reductase
Chromosome	1p31.3
Protein Family	FAD-dependent oxidoreductases
Protein Type	Enzyme
Function	encodes an enzyme involved in the final step of cholesterol biosynthesis, converting 24-dehydrocholesterol to cholesterol.
Primary Expression	the brain and essential for neuronal survival
Subcellular Localization	Endoplasmic reticulum, lipid rafts
Molecular Weight	56 kDa
Amino Acids	489 aa
Pathways	Viral Uptake, epigenetic regulation, unfolded protein response
UniProt ID	Q8N0Y2
NCBI Gene ID	1719
Ensembl ID	ENSG00000116133
OMIM	606417
GeneCards	DHCR24
Human Protein Atlas	DHCR24
Associated Diseases	AD, Als, Alzheimer, Alzheimer's disease, AMI, disease
Known Drugs/Compounds	rapamycin
Interactions	A2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE
KG Connections	110 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DHCR24 — AlphaFold Q8N0Y2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DHCR24 Gene

gene · 666 words

→

DHCR24 Protein

protein · 625 words

→

Pathway Diagram

graph TD
    DHCR24["DHCR24"] -->|"interacts"| Alzheimer["Alzheimer"]
    DHCR24["DHCR24"] -->|"interacts"| Tumor["Tumor"]
    DHCR24["DHCR24"] -->|"interacts"| Als["Als"]
    DHCR24["DHCR24"] -->|"expressed in"| Atherosclerosis["Atherosclerosis"]
    DHCR24["DHCR24"] -->|"interacts"| ALS["ALS"]
    DHCR24["DHCR24"] -->|"associated"| HMGCR["HMGCR"]
    NCSTN["NCSTN"] -->|"interacts"| DHCR24["DHCR24"]
    FAS["FAS"] -->|"interacts"| DHCR24["DHCR24"]
    TNF["TNF"] -->|"interacts"| DHCR24["DHCR24"]
    LMNA["LMNA"] -->|"interacts"| DHCR24["DHCR24"]
    style DHCR24 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (67)

Target	Relation	Type	Str
Viral Uptake	involved_in	mechanism	0.80
ALZHEIMER'S DISEASE	associated_with	entity	0.70
Alzheimer	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
GENES	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
Lipid Metabolism	expressed_in	pathway	0.60
Cholesterol	expressed_in	pathway	0.60
TFCP2	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
Wnt signaling	participates_in	pathway	0.60
HMGCR	associated_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
Cholesterol	associated_with	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
SREBF2	associated_with	gene	0.60
LPL	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	associated_with	gene	0.60
FAS	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
PSD95	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
PSD95	targets	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DNA	associated_with	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
Kinesin	interacts_with	protein	0.60
Amyloid	interacts_with	pathway	0.60

Incoming (43)

Source	Relation	Type	Str
APOPTOSIS	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
HMGCR	associated_with	gene	0.60
BDNF	targets	gene	0.60
BDNF	expressed_in	gene	0.60
DNA	interacts_with	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
ACC	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
ABCA1	associated_with	gene	0.60
HSPG2	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
MAPT	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
ABCG1	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
TFCP2	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DNA	associated_with	gene	0.60
A2M	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
APOE Ε4	associated_with	gene	0.60
rapamycin	targets	drug	0.60
LMNA	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	associated_with	gene	0.60
PSEN2	interacts_with	gene	0.60
APOE4	activates	gene	0.55
late	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DHCR24 in their description or question text

No additional research found