gene 2,366 words KG: ent-gene-b2e5ccd6
Contents

ABCG1 Gene

🧬 Gene Info
Gene SymbolABCG1
Full NameATP-Binding Cassette Subfamily G Member 1
Chromosome21q22.3
Protein TypeTransporter
Functionis a critical lipid transporter protein that plays a fundamental role in cellular cholesterol and phospholipid homeostasis.
Primary Expressionneurons, astrocytes, microglia, and oligodendrocytes, where it regulates brain lipid homeostasis and protects against neurodegeneration[@tansley2007][
Molecular Weight67 kDa
Exons23
PathwaysCholesterol
UniProt IDP45878
NCBI Gene ID26273
Ensembl IDENSG00000160179
OMIM603076
GeneCardsABCG1
Human Protein AtlasABCG1
Associated DiseasesAD, Als, Alzheimer, AMI, ARM
Known Drugs/Compoundsquercetin
Interactions4E-BP1, ABCA1, ABCA7, ACTB, Actin, AKT
KG Connections244 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (25)

CYP46A1 Overexpression Gene Therapy
Score: 0.73
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
PARP1 Inhibition Therapy
Score: 0.74
Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
pg 1/2Next →

Related Analyses (6)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: activates
ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2
gene · KG edge: expressed_in
ABCD3 Gene
gene · KG edge: expressed_in
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: expressed_in
ABCG4 Gene — ATP-Binding Cassette Subfamily G Member 4
gene · KG edge: regulates

Knowledge Graph (6 edges)

h-bc8867b7ad targets ent-gene-b2e5ccd6
ent-gene-b2e5ccd6 targeted_by h-bc8867b7ad
h-3f4cb83e0c targets ent-gene-b2e5ccd6
ent-gene-b2e5ccd6 targeted_by h-3f4cb83e0c
ent-gene-b2e5ccd6 data_in benchmark_ot_ad_answer_key:ABCG1
benchmark_ot_ad_answer_key:ABCG1 data_in ent-gene-b2e5ccd6

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.