protein 943 words KG: ABCG1PROTEIN
Contents

ABCG1 Protein

🔬 Protein Info
Gene SymbolABCG1
Full NameATP-Binding Cassette Subfamily G Member 1
Chromosome21q22.3
Protein TypeTransporter
Functionis a critical lipid transporter protein that plays a fundamental role in cellular cholesterol and phospholipid homeostasis.
Primary Expressionneurons, astrocytes, microglia, and oligodendrocytes, where it regulates brain lipid homeostasis and protects against neurodegeneration[@tansley2007][
Molecular Weight67 kDa
Exons23
PathwaysCholesterol
UniProt IDP45878
NCBI Gene ID26273
Ensembl IDENSG00000160179
OMIM603076
GeneCardsABCG1
Human Protein AtlasABCG1
Associated DiseasesAD, Als, Alzheimer, AMI, ARM
Known Drugs/Compoundsquercetin
Interactions4E-BP1, ABCA1, ABCA7, ACTB, Actin, AKT
KG Connections247 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (15)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 3 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 3 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

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