Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LAMP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LAMP3 |
| Full Name | Lysosomal Associated Membrane Protein 3 |
| Chromosome | 3q27.2. |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | mature dendritic cells and plays critical roles in: - MHC class II antigen presentation: Colocalizes with MHC class II compartments - Immune syn |
| Subcellular Localization | </strong></td><td>Lysosomes, Late Endosomes, Cell Surface (dendritic cells)</td></tr> |
| Molecular Weight | 61.7 kDa |
| UniProt ID | [Q9UQ15](https://www.uniprot.org/uniprot/Q9UQ15) |
| Ensembl ID | ENSG00000046651 |
| GeneCards | LAMP3 |
| Human Protein Atlas | LAMP3 |
| Lumenal domain | Large heavily glycosylated region containing multiple N-linked glycosylation sites (up to 29 potential sites) |
| Transmembrane domain | Single pass alpha-helical segment |
| Cytoplasmic tail | Short tail containing trafficking signals (YXXφ motif) |
| MHC class II antigen presentation | Colocalizes with MHC class II compartments |
| Associated Diseases | neurodegeneration |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["LAMP3"]
N1["Als"]
N0 -->|"expressed in"| N1
N2["ABCG1"]
N0 -->|"expressed in"| N2
N3["WTAP"]
N0 -->|"expressed in"| N3
N4["RORA"]
N0 -->|"expressed in"| N4
N5["TGM2"]
N0 -->|"expressed in"| N5
N6["PIK3R1"]
N0 -->|"expressed in"| N6
N7["NR1D2"]
N7 -->|"expressed in"| N0
N8["CKAP4"]
N8 -->|"expressed in"| N0
N9["GAIN"]
N9 -->|"expressed in"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene
class N9 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LAMP3 in their description or question text
No additional research found