gene

GBA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1590Connections

7Hypotheses

3Analyses

50Outgoing

50Incoming

2Experiments

3Debates

Summary

GBA is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with AD, ALI, ALS. Connected to 591 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GBA
Function	is a critical gene in the intersection of lysosomal storage disorders and neurodegenerative diseases.
Molecular Weight	60 kDa
Amino Acids	536 aa
Pathways	Amyloid, Autophagy, Autophagy-Lysosomal Pathway, Chaperone, Epigenetic
Ensembl ID	ENSG00000177628
GeneCards	GBA
Human Protein Atlas	GBA
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	AAV.GMU01_SS3-GBA1, glucosylceramide, NCGC00188758
Interactions	ABCD3, ACHE, Actin, AD, AGING, ALPHA-SYNUCLEIN
SciDEX Hypotheses	Glucosylceramide accumulation nucleates alpha-synu
KG Connections	1588 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure Comparison — GBA Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

2V3D — X-ray / Cryo-EM

🔮 AI Predicted Structure

P04062 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GBA["GBA"] -->|"causes"| mitochondrial_dysfunction["mitochondrial dysfunction"]
    GBA["GBA"] -.->|"inhibits"| autophagy["autophagy"]
    GBA["GBA"] -.->|"inhibits"| mitophagy["mitophagy"]
    GBA["GBA"] -->|"contributes to"| Parkinson_disease["Parkinson disease"]
    GBA["GBA"] -->|"contributes to"| Parkinson_s_disease["Parkinson's disease"]
    GBA["GBA"] -->|"activates"| Parkinson["Parkinson"]
    Parkinson_1["Parkinson"] -->|"interacts"| GBA["GBA"]
    CAT["CAT"] -->|"interacts"| GBA["GBA"]
    OPTN["OPTN"] -->|"interacts"| GBA["GBA"]
    DNM1L["DNM1L"] -->|"interacts"| GBA["GBA"]
    style GBA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (995)

Target	Relation	Type	Str
GBA	encodes	protein	0.00
GLUCOCEREBROSIDASE	associated_with	protein	1.00
GLUCOCEREBROSIDASE	expresses	protein	1.00
GAUCHER_DISEASE	causes	disease	1.00
right pars triangularis volume	causes	brain_region	0.98
Lewy body pathology	associated_with	phenotype	0.98
Parkinson'S Disease	risk_factor_for	disease	0.95
Gaucher's disease	causes	disease	0.95
GCASE	encodes	enzyme	0.95
Glucocerebrosidase	encodes	enzyme	0.95
Parkinson's Disease	associated_with	disease	0.95
Parkinson Disease	risk_factor_for	disease	0.95
GLUCOSYLCERAMIDASE	encodes	enzyme	0.95
Gaucher Disease	causes	disease	0.95
Glucosylceramide Accumulation	causes	phenotype	0.93
Gaucher disease	causes	disease	0.90
LYSOSOMAL DYSFUNCTION	regulates	phenotype	0.90
Glucocerebrosidase	associated_with	enzyme	0.90
oxidative stress response	participates_in	pathway	0.90
PARKINSONISM	associated_with	disease	0.90
PARKINSON_DISEASE	associated_with	disease	0.90
synucleinopathies	associated_with	disease	0.90
L483P	associated_with	gene	0.90
PARKINSON_GBA1	causes	disease	0.90
N409S	associated_with	gene	0.90
Parkinson's disease	associated_with	disease	0.90
Glucocerebrosides	associated_with	chemical	0.90
gut-brain axis	participates_in	pathway	0.90
mitochondrial dysfunction	causes	phenotype	0.90
mitophagy	inhibits	pathway	0.90
Parkinson disease	contributes_to	disease	0.90
autophagy	inhibits	pathway	0.90
Autophagy-Lysosomal Pathway	regulates	pathway	0.88
SNCA	prevents_aggregation	gene	0.85
Glucosylceramidase Beta 1	activates	protein	0.85
Autophagy	associated_with	process	0.85
Alpha-Synuclein Neurotoxicity	modulates	phenotype	0.85
Parkinson'S Disease	involved_in	disease	0.85
Als	associated_with	disease	0.85
lysosomal degradation	involved_in	process	0.85
α-synuclein neurotoxicity	modulates	phenotype	0.85
putamen volume	regulates	brain_region	0.82
Lewy body dementia	associated_with	disease	0.80
non-manifesting carriers	expressed_in	cell_type	0.80
DEMENTIA_WITH_LEWY_BODIES	associated_with	disease	0.80
LYSOSOMAL_DYSFUNCTION	causes	pathway	0.80
T408M	associated_with	gene	0.80
GLYCOSPHINGOLIPID_CATABOLISM	part_of	pathway	0.80
ALPHA_SYNUCLEIN	interacts_with	protein	0.80
alpha-synuclein	regulates	protein	0.80

Incoming (595)

Source	Relation	Type	Str
GBA	encodes	gene	0.00
entities-histone-modifications	interacts_with	wiki	0.00
PARKINSON'S DISEASE	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
genes-gba	linked_to	wiki	1.00
rs75548401	associated_with	compound	0.92
NEURODEGENERATION	associated_with	gene	0.90
LRRK2	interacts_with	gene	0.85
LRRK2	converges_with	gene	0.85
MICROGLIA	associated_with	cell_type	0.74
AMYLOID	associated_with	gene	0.74
DOPAMINERGIC	expresses	cell_type	0.70
APOE	expresses	gene	0.70
ASTROCYTE	associated_with	cell_type	0.70
CGAS	causes	gene	0.70
ACHE	inhibits	gene	0.70
C9ORF72	regulates	gene	0.70
ACHE	interacts_with	gene	0.70
APOE	inhibits	gene	0.70
ENDOTHELIAL	activates	cell_type	0.70
AMYOTROPHIC LATERAL SCLEROSIS	activates	disease	0.70
DOPAMINERGIC	protects_against	cell_type	0.70
FTD	interacts_with	disease	0.70
PARKINSON'S DISEASE	activates	gene	0.70
ALPHA-SYNUCLEIN	causes	gene	0.70
LRRK2	associated_with	gene	0.70
Parkinson	interacts_with	disease	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
PARKINSON	therapeutic_target	gene	0.70
SNCA	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.66
FRONTOTEMPORAL DEMENTIA	causes	disease	0.65
ATP	activates	gene	0.65
NEURONS	produces	cell_type	0.65
ACHE	protects_against	gene	0.65
DEPRESSION	increases_risk	disease	0.65
APOE	associated_with	gene	0.65
LEVODOPA	associated_with	drug	0.65
BIN1	co_discussed	gene	0.65
APOE	co_discussed	gene	0.65
DEMENTIA	regulates	disease	0.65
CR2	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
IL6	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
CTSH	associated_with	gene	0.60
PILRB	associated_with	gene	0.60
GCASE	degrades	gene	0.60
PLIN2	causes	gene	0.60

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9	0.750	neurodegeneration	-
GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Si	0.747	neurodegeneration	-
PD-Associated GWAS Variants in CTSO and CTSF Genes Create a	0.743	neurodegeneration	-
Lysosomal Acidification Failure: Convergent GBA1/LAMP2A–medi	0.700	neurodegeneration	-
VPS35 Retromer Dysfunction Creates a GCase Trafficking Bottl	0.700	neurodegeneration	-

Glucosylceramide accumulation nucleates alpha-synuclein aggr	0.525	Parkinson's disease	GBA-Synuclein Loop Therapeutics for PD
Glucosylceramide-mediated feedback loop drives GBA-synuclein	0.380	Parkinson's disease	GBA-Synuclein Loop: Therapeutic Strategi

Mentioning Analyses (3)

Scientific analyses that reference this entity

Does TFEB activation directly restore mutant GBA enzyme activity or only enhance

molecular biology | 2026-04-11 | 0 hypotheses

GBA-Synuclein Loop Therapeutics for PD

neurodegeneration | 2026-04-01 | 1 hypotheses Top: 0.525

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease

neurodegeneration | 2026-04-01 | 1 hypotheses Top: 0.380

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Pain has been frequently reported as an initial symptom and the most t	genetic_association	Parkinson's disease	0.500	0.00	human	extracted	N/A
Validate Mitochondria-Lysosome Contact Site Dysfunction in PD	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

The debate identified this as a critical mechanistic gap - TFEB may increase lys

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

GBA-Synuclein Loop: Therapeutic Strategies for Parkinson's Disease?

closed · Rounds: 4 · Score: 0.89 · 2026-04-10

How to break the GBA-alpha-synuclein bidirectional loop for Parkinson's Disease

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning GBA in their description or question text

Glucosylceramide accumulation nucleates alpha-synuclein aggregation via lipid ra

Score: 0.525 · Parkinson's disease · 2026-04-26

We propose that GBA deficiency-driven accumulation of glucosylceramide (GlcCer) in lysosomal membranes creates ordered l

Glucosylceramide-mediated feedback loop drives GBA-synuclein pathology

Score: 0.380 · Parkinson's disease · 2026-04-27

In GBA-associated PD, reduced glucocerebrosidase activity leads to glucosylceramide accumulation in neurons and glia, wh

GBA

Understanding Entity Pages

Summary

Wiki Pages (21)

gba

GBA Pathway in Parkinson's Disease

GBA1→GCase→Lysosome→PD Causal Chain

GBA1 Protein (Glucocerebrosidase)

GBA Gene Mutations and Parkinson's Disease Risk

GBA Glucocerebrosidase Endolysosomal Pathway in Parkinson's Disease

LRRK2-GBA Combination Therapy for Parkinson's Disease

BIA 28-6156 for GBA-Parkinson's Disease

GBA and Lysosomal Function in Parkinson's Disease

GBA Glucocerebrosidase Dysfunction and Parkinson's Disease

GBA N370S

LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develop PD

ONCOGBA: Malignant Neoplasms Incidence in GBA-PD (NCT06814431)

GBA1 Gaucher Disease Modulator for Parkinson's Disease

GBA Glucocerebrosidase Pathway in Parkinson's Disease

GBA Therapy in Parkinson's Disease

GBAP1

GBA1 (Glucocerebrosidase) Protein

GBA1 — Glucocerebrosidase

GBA2 Protein - Non-lysosomal Glucosylceramidase

GBA Gene Therapy for Parkinson's Disease