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gene 3,783 words KG: GBA
Contents

GBA Gene

🧬 Gene Info
Gene SymbolGBA
Functionis a critical gene in the intersection of lysosomal storage disorders and neurodegenerative diseases.
Molecular Weight60 kDa
Amino Acids536 aa
PathwaysAmyloid, Autophagy, Autophagy-Lysosomal Pathway, Chaperone, Epigenetic
Ensembl IDENSG00000177628
GeneCardsGBA
Human Protein AtlasGBA
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
Known Drugs/CompoundsAAV.GMU01_SS3-GBA1, glucosylceramide, NCGC00188758
InteractionsABCD3, ACHE, Actin, AD, AGING, ALPHA-SYNUCLEIN
KG Connections1679 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (23)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.92APOE-Dependent Autophagy Restoration
Score: 0.85Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (10)

GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completedAstrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archivedMicroglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedAutophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (12)

Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40MLCS Quantification in Parkinson's Disease
validation · proposed · Score: 0.40Experiment: Multi-Ethnic PD GWAS
clinical · proposed · Score: 0.40Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: associated_withABCD3 Gene
gene · KG edge: activatesADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: associated_withAKT1 Gene
gene · KG edge: therapeutic_targetActin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed

Knowledge Graph (12 edges)

CAT interacts_with GBA
OPTN interacts_with GBA
DNM1L interacts_with GBA
CANX interacts_with GBA
LGALS3 interacts_with GBA
CALCOCO2 interacts_with GBA
G3BP1 interacts_with GBA
PEX3 interacts_with GBA
SQSTM1 interacts_with GBA
BCL2 interacts_with GBA

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