concept

GUT-BRAIN AXIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GUT-BRAIN AXIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

759Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

GUT-BRAIN AXIS is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 344 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GUT-BRAIN AXIS
Key Genes/Proteins	AGING, AKT, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Adaptive Immunity, Akt, Alpha-Synuclein

Pathway Diagram

graph TD
    GUT_BRAIN_AXIS["GUT-BRAIN AXIS"]
    GUT_BRAIN_AXIS -->|"target for"| Inflammation["Inflammation"]
    GUT_BRAIN_AXIS -->|"target for"| Schizophrenia["Schizophrenia"]
    GUT_BRAIN_AXIS -->|"target for"| Autism["Autism"]
    GUT_BRAIN_AXIS -->|"target for"| Anxiety["Anxiety"]
    GUT_BRAIN_AXIS -->|"target for"| Neuroinflammation["Neuroinflammation"]
    GUT_BRAIN_AXIS -->|"target for"| Bipolar["Bipolar"]
    GUT_BRAIN_AXIS -->|"target for"| Ms["Ms"]
    GUT_BRAIN_AXIS -->|"activates"| Als["Als"]
    gut_vascular_barrier["gut vascular barrier"] -->|"regulates"| GUT_BRAIN_AXIS
    vagus_nerve["vagus nerve"] -->|"regulates"| GUT_BRAIN_AXIS
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| GUT_BRAIN_AXIS
    DRP1["DRP1"] -->|"activates"| GUT_BRAIN_AXIS
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| GUT_BRAIN_AXIS
    TPH2["TPH2"] -->|"activates"| GUT_BRAIN_AXIS
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| GUT_BRAIN_AXIS
    ANXIETY["ANXIETY"] -->|"activates"| GUT_BRAIN_AXIS

Outgoing (443)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Als	regulates	disease	0.95
Sepsis-Associated Encephalopathy	involved_in	disease	0.95
Neuroinflammation	activates	disease	0.95
Central Nervous System	mediates	process	0.95
Inflammation	therapeutic_target	disease	0.95
Cognitive Impairment	modulates	phenotype	0.90
Brain Homeostasis	associated_with	process	0.90
Cognitive Impairment	regulates	phenotype	0.90
Sepsis-Associated Encephalopathy	contributes_to	disease	0.90
Central Nervous System Inflammation	associated_with	process	0.90
CNS Inflammation	contributes_to	process	0.90
Neurodegenerative Disorders	associated_with	disease	0.90
Alzheimer'S Disease Progression	modulates	phenotype	0.90
Parkinson'S Disease	involved_in	disease	0.90
NEUROINFLAMMATION	activates	gene	0.90
Microbiota	activates	pathway	0.90
Alzheimer's Disease Progression	modulates	phenotype	0.88
Als	therapeutic_target	disease	0.85
Brain	mediates	cell_type	0.85
Als	activates	disease	0.85
Parkinson's Disease	associated_with	disease	0.85
Alzheimer	therapeutic_target	disease	0.85
Cognitive Dysfunction	involved_in	phenotype	0.85
ALZHEIMER'S DISEASE	involved_in	disease	0.85
Central Nervous System	modulates	cell_type	0.85
Alzheimer's Disease	associated_with	disease	0.85
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
Central Nervous System Physiology	regulates	process	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Inflammation	associated_with	disease	0.85
PARKINSON'S DISEASE	involved_in	disease	0.85
depression	modulates	disease	0.85
Parkinson	activates	disease	0.85
Neurodegeneration	activates	disease	0.85
Parkinson	associated_with	disease	0.85
Cognition	modulates	phenotype	0.85
Neuroinflammation	modulates	process	0.82
lipid metabolism	regulates	process	0.82
INFLAMMATION	associated_with	gene	0.80
Depression	associated_with	disease	0.80
neuropsychiatric disorders	implicated_in	disease	0.80
Alzheimer Disease	associated_with	disease	0.80
Parkinson's disease	mediates	disease	0.80
Neuroinflammation	contributes_to	process	0.80
MICROGLIA	activates	gene	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
Microbiota	therapeutic_target	pathway	0.80
Parkinson	therapeutic_target	disease	0.75
Alzheimer	associated_with	disease	0.75

Incoming (316)

Source	Relation	Type	Str
SDA-2026-04-01-gap-20260401-225155	investigates	analysis	0.95
Microbiota	regulates	process	0.95
Gut Microbiota	component_of	process	0.95
Microbiota	component_of	process	0.95
Gut Microbiota	regulates	process	0.95
gut microbiota	regulates	cell_type	0.92
Bacterial Metabolites	component_of	compound	0.90
Neural Communication	component_of	pathway	0.90
GBA	participates_in	gene	0.90
gut microbiota dysbiosis	disrupts	phenotype	0.88
Gut Microbiota Dysbiosis	involved_in	biomarker	0.85
SNCA	involved_in	protein	0.85
Acetate	involved_in	compound	0.85
Pcs	modulates	compound	0.85
Immune System	component_of	process	0.85
HPA Axis	component_of	pathway	0.85
Vagus Nerve	component_of	process	0.85
Short-Chain Fatty Acids	involved_in	compound	0.85
Gut Dysbiosis	causes	phenotype	0.85
Enteric Glia	involved_in	cell_type	0.80
BDNF	participates_in	gene	0.80
Serotonin	component_of	compound	0.80
PARKINSON'S DISEASE	associated_with	gene	0.80
INFLAMMATION	activates	gene	0.80
PARKINSON	associated_with	gene	0.80
neuroinflammation	involves	disease	0.75
BDNF	involved_in	protein	0.75
gut vascular barrier	regulates	process	0.70
vagus nerve	regulates	process	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
Parkinson'S Disease	associated_with	disease	0.70
PARKINSON	activates	gene	0.70
INFLAMMATION	associated_with	gene	0.70
ALS	participates_in	gene	0.70
PARKINSON'S DISEASE	regulates	gene	0.70
NEURODEGENERATION	activates	gene	0.70
NLRP3	participates_in	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
gut barrier integrity	mediates	phenotype	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
neurodegeneration	involves	disease	0.65
GBA1	interacts_with	gene	0.65
NF-ΚB	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
OXIDATIVE STRESS	treats	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gut-Brain Axis M-Cell Modulation	0.629	-	Neuroinflammation and microglial priming
Gut-Brain Axis Microbiome Modulation	0.585	Alzheimer's disease	Neuroinflammation and microglial priming

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
AhR transcriptional regulation of NEP gene	exploratory	Alzheimer's disease	0.850	0.00	Cell culture system	proposed	N/A

Related Papers (11)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology [PMID:38750854]	He C, Jiang J, Liu J, Zhou L, Ge Y, Yang	International journal of biolo	2024	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840]	Tortelote GG	Pediatr Nephrol	2026	0
Exploring the gut-kidney axis: Berberine's role in alleviating chronic kidney di [PMID:41344525]	Lu Z, Li Z, Gu S, Cai Y, Wu Y et al.	J Ethnopharmacol	2026	0
Rebalancing the inflammatory niche in allergic rhinitis ". [PMID:41360358]	Wang N, Tang Y	Clin Chim Acta	2026	0
Differentiating Damp-Heat and Cold-Damp Diarrhea in Rat Models via Gut Microbiot [PMID:41566926]	Zhang H, Song X, Mi W, Ji P, Wei Y et al	Microbiologyopen	2026	0
Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408]	Cattero V, Mayer T, Veilleux A, Roussel	Scientific reports	2026	0
Exploring the Role of Microglial Cells in the Gut-Brain Axis Communication: A Sy [PMID:40662222]	Ortiz-Samur NS, Vijaya AK, Burokas A, Me	Journal of neurochemistry	2025	0
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease. [PMID:39321881]	Bano N, Khan S, Ahamad S, Kanshana JS, D	Ageing research reviews	2024	0
The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidati [PMID:39460538]	["Yang Jianshe", "Liang Junyi", "Hu Niyu	CNS neuroscience & therapeutic	2024	0
Brain-Gut-Microbiota Axis in Alzheimer's Disease. [PMID:30646475]	["Kowalski Karol", "Mulak Agata"]	Journal of neurogastroenterolo	2019	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GUT-BRAIN AXIS in their description or question text

No additional research found