protein

GCase

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCase: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

0Hypotheses

0Analyses

50Outgoing

18Incoming

0Experiments

0Debates

Summary

A protein referenced in 5 knowledge graph relationships. Key connections: GBA1 (gene) encodes; maintains lysosomal_function (mechanism); alpha_synuclein_aggregation (mechanism) inhibits.

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🔬 Protein Info

Gene Symbol	GCASE
Primary Expression	Substantia Nigra
Pathways	Alpha-Synuclein, Unfolded Protein Response, Er Stress, Mitochondrial Function
GeneCards	GCASE
Human Protein Atlas	GCASE
Associated Diseases	disease
KG Connections	3 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GCASE["GCASE"]
    GCASE -->|"cleaves"| Glucocerebrosides["Glucocerebrosides"]
    GCASE -->|"causes"| Senescence["Senescence"]
    GCASE -->|"causes"| Parkinson["Parkinson"]
    GCASE -->|"causes"| Neurodegeneration["Neurodegeneration"]
    GCASE -->|"causes"| Aging["Aging"]
    GCASE -->|"interacts"| Ms["Ms"]
    GBA["GBA"] -->|"encodes"| GCASE
    PLIN2["PLIN2"] -->|"causes"| GCASE
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"causes"| GCASE
    NEURON["NEURON"] -->|"causes"| GCASE
    AGING["AGING"] -->|"causes"| GCASE
    PARKINSON["PARKINSON"] -->|"activates"| GCASE

Outgoing (60)

Target	Relation	Type	Str
Glucocerebrosides	cleaves	compound	0.90
Synucleinopathies	risk_factor_for	disease	0.85
LRRK2	interacts_with	protein	0.80
Ms	causes	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Parkinson	encodes	disease	0.65
Lewy Body	encodes	disease	0.65
Neuroinflammation	causes	disease	0.65
Dementia	encodes	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Senescence	causes	disease	0.65
Parkinson	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Aging	causes	disease	0.65
Neurodegeneration	activates	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	activates	disease	0.65
ALS	activates	disease	0.65
LYSOSOME	inhibits	gene	0.60
PLIN2	causes	gene	0.60
GBA	degrades	gene	0.60
ATP13A2	activates	gene	0.60
Neuron	causes	cell_type	0.60
AND	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
Dopaminergic	causes	cell_type	0.60
Dopaminergic	activates	cell_type	0.60
Stem Cell	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
GBA	encodes	gene	0.60
PARKINSON	activates	gene	0.60
GBA	associated_with	gene	0.60
AND	causes	gene	0.60
Actin	activates	protein	0.60
GBA1	associated_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
Mitochondrial Function	causes	pathway	0.60
Microglia	activates	cell_type	0.60
CHOP	activates	gene	0.60
GBA1	causes	gene	0.60
DEMENTIA	encodes	gene	0.60
STING	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
DNA	causes	gene	0.60
PARKINSON	encodes	gene	0.60
MTDNA	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AGING	causes	gene	0.60
Alpha-Synuclein	causes	pathway	0.60

Incoming (18)

Source	Relation	Type	Str
GBA1	expresses	gene	1.00
GBA	encodes	gene	0.95
Ambroxol	activates	drug	0.90
AND	associated_with	gene	0.60
GBA1 VARIANTS	causes	gene	0.60
PLIN2	causes	gene	0.60
GBA	degrades	gene	0.60
PARKINSON	activates	gene	0.60
BIP	activates	gene	0.60
GBA	cleaves	entity	0.60
ALPHA-SYNUCLEIN	causes	gene	0.60
NEURON	causes	gene	0.60
AGING	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
PARKINSON	causes	gene	0.60
AND	causes	gene	0.60
GBA1	causes	gene	0.60
GBA1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GCase in their description or question text

No additional research found

GCase

Understanding Entity Pages

Summary

Wiki Pages (6)

GBA1→GCase→Lysosome→PD Causal Chain

Ambroxol for Neurodegeneration (GCase Chaperone Strategy)

Glucocerebrosidase (GCase)

Glucocerebrosidase (GCase) - Biomarker

NCT05565443: MR-Guided Focused Ultrasound + GCase for Parkinson's Disease

GCase and Lysosomal Function in Parkinson's Disease