protein 1,252 words KG: GBA2PROTEIN
Contents

GBA2 Protein - Non-lysosomal Glucosylceramidase

🔬 Protein Info
Gene SymbolGBA2
Full NameGlucosylceramidase Beta 2
AliasesPage for GBA2 Gene, Page for GBA2 Protein
Chromosome9q34.2
Protein TypeEnzyme
FunctionGBA2 is a member of the glycoside hydrolase family 4.
Primary Expressionvarious tissues including brain, liver, and testis
Molecular Weight95 kDa
Amino Acids846 aa
UniProt IDQ9HCG6
NCBI Gene ID57733
Ensembl IDENSG00000143633
GeneCardsGBA2
Human Protein AtlasGBA2
N-terminal transmembrane helixAnchors the protein to cellular membranes (ER, plasma membrane)
Associated Diseasesneurodegeneration
DatabasesGeneCardsHPASTRING

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Related Hypotheses (9)

Lysosomal Enzyme Trafficking Correction
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (15)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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