mechanism 3,927 words KG: ent-gene-55fa8e24
Contents

GBA1→GCase→Lysosome→PD Causal Chain

🔬 Protein Info
Gene Symbolent-gene-55fa8e24
FunctionGlucocerebrosidase (GCase)
pH gradientoptimal activity at acidic lysosomal pH (~5)
ER chaperonesproper folding in endoplasmic reticulum
Brain30-40% reduction
Blood40-70% reduction
Fibroblasts30-50% reduction
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

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Related Hypotheses (11)

Microbial Inflammasome Priming Prevention
Score: 0.65
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Transcriptional Autophagy-Lysosome Coupling
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Autophagosome Maturation Checkpoint Control
Score: 0.71
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
VCP-Mediated Autophagy Enhancement
Score: 0.59
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48
APOE-Dependent Autophagy Restoration
Score: 0.88
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Sphingolipid Metabolism Reprogramming
Score: 0.62

Related Analyses (29)

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Related Experiments (10)

Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Leukocyte gene expression analysis in COVID-19 patients
exploratory · proposed · Score: 0.90
Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90
RBG treatment in ApoE-/- atherosclerosis mouse model
validation · proposed · Score: 0.90

Knowledge Graph (2 edges)

ent-gene-55fa8e24 data_in benchmark_ot_ad_answer_key:GBA1
benchmark_ot_ad_answer_key:GBA1 data_in ent-gene-55fa8e24

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