| Gene Symbol | GBA1PROTEIN |
| Protein Type | Hydrolase |
| Function | is a lysosomal hydrolase encoded by the GBA1 gene that catalyzes the hydrolysis of glucosylceramide to ceramide and glucose. |
| Subcellular Localization | </th><td>Lysosome</td></tr> |
| Amino Acids | 536 aa |
| GeneCards | GBA1PROTEIN |
| Human Protein Atlas | GBA1PROTEIN |
| Signal peptide (1-19) | Directs protein to lysosome |
| Propeptide (20-39) | Cleaved during maturation |
| Catalytic domain (40-536) | Contains active site |
| Active site residues | Glu235 (nucleophile), Glu349 (acid/base) |
| N-glycosylation sites | Asn59, Asn146, Asn190 |
| Saposin C binding site | Required for in vivo activity |
| Dimer interface | Forms functional homodimer |
| 1OGS | Native GCase structure |
| Associated Diseases | Aging, Als, Alzheimer, Cancer, dementia with Lewy bodies |
| Known Drugs/Compounds | AAV5, AAV9, Ambroxol, Bi-Htfr1, BI-hTFR1, levodopa |
| Interactions | ABCA1, Actin, AKT, ALPHA-SYNUCLEIN, AMPK, AND |
| KG Connections | 421 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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