concept

PYRAMIDAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PYRAMIDAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

220Connections

0Hypotheses

0Analyses

19Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

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💡 Concept Info

Name	PYRAMIDAL
Key Genes/Proteins	ACHE
Related Diseases	ALS

Pathway Diagram

graph TD
    PYRAMIDAL["PYRAMIDAL"]
    style PYRAMIDAL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PYRAMIDAL -->|"expressed in"| Cortex((Cortex))
    PYRAMIDAL -->|"expressed in"| Spinal_Cord((Spinal Cord))
    PYRAMIDAL -->|"expressed in"| Temporal_Lobe((Temporal Lobe))
    PYRAMIDAL -->|"expressed in"| Hippocampus((Hippocampus))
    PYRAMIDAL -->|"expressed in"| Prefrontal_Cortex((Prefrontal Cortex))
    NEURODEGENERATION["NEURODEGENERATION"] -->|"contributes to"| PYRAMIDAL
    ASTROCYTE["/ASTROCYTE/"] -->|"expressed in"| PYRAMIDAL
    ASTROCYTES["/ASTROCYTES/"] -->|"expressed in"| PYRAMIDAL
    MICROGLIA["/MICROGLIA/"] -->|"expressed in"| PYRAMIDAL
    CORTEX((CORTEX)) -->|"reduces"| PYRAMIDAL
    DNA_DAMAGE["DNA DAMAGE"] -->|"reduces"| PYRAMIDAL
    NEURON["/NEURON/"] -->|"reduces"| PYRAMIDAL
    NEURONS["/NEURONS/"] -->|"reduces"| PYRAMIDAL

Outgoing (19)

Target	Relation	Type	Str
Cortex	expressed_in	brain_region	0.50
Spinal Cord	expressed_in	brain_region	0.50
Hippocampus	expressed_in	brain_region	0.50
Prefrontal Cortex	expressed_in	brain_region	0.50
SYNAPSE	co_discussed	entity	0.50
SQSTM1	co_discussed	entity	0.50
SOD1	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
SCHIZOPHRENIA	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
Temporal Lobe	expressed_in	brain_region	0.50

Incoming (201)

Source	Relation	Type	Str
ASTROCYTE	expressed_in	cell_type	0.65
NEURON	contributes_to	cell_type	0.65
NEURONS	reduces	cell_type	0.65
NEURON	reduces	cell_type	0.65
CORTEX	reduces	brain_region	0.65
ASTROCYTES	expressed_in	cell_type	0.65
NEURODEGENERATION	contributes_to	disease	0.65
MICROGLIA	expressed_in	cell_type	0.65
BCL2	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
AMYLOID	activates	gene	0.60
NEURON	expressed_in	gene	0.60
ASTROCYTES	expressed_in	gene	0.60
MICROGLIA	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
RNA	activates	gene	0.60
PRESENILIN	protects_against	gene	0.60
ALZHEIMER	protects_against	gene	0.60
AMPK	protects_against	gene	0.60
NEURON	degrades	gene	0.60
ERK	inhibits	gene	0.60
HUNTINGTON	inhibits	gene	0.60
NEURON	associated_with	gene	0.60
GFAP	inhibits	gene	0.60
TAU	therapeutic_target	gene	0.60
TDP-43	therapeutic_target	gene	0.60
ASC	activates	gene	0.60
NLRP3	activates	gene	0.60
GSDMD	expressed_in	gene	0.60
TDP-43	activates	gene	0.60
NEURON	expressed_in	cell_type	0.60
NEURONS	expressed_in	cell_type	0.60
DEMENTIA	causes	disease	0.60
FRONTOTEMPORAL	causes	disease	0.60
CORTEX	contributes_to	brain_region	0.60
NEURON	impairs	cell_type	0.60
FTLD	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
GASDERMIN	activates	gene	0.60
DNA	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
TRKB	inhibits	gene	0.60
ADAM10	causes	gene	0.60
NEURON	regulates	gene	0.60
ACC	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PYRAMIDAL in their description or question text

No additional research found