SciDEX — MONOCYTES

graph TD
    MONOCYTES["MONOCYTES"]
    style MONOCYTES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MONOCYTES -->|"mediates"| Pro_inflammatory_Signals["Pro-inflammatory Signals"]
    MONOCYTES -->|"causes"| STROKE["STROKE"]
    MONOCYTES -->|"interacts"| NECROPTOSIS["NECROPTOSIS"]
    MONOCYTES -->|"accumulates_in"| NEUTROPHIL["/NEUTROPHIL/"]
    MONOCYTES -->|"interacts"| BBB((BBB))
    MONOCYTES -->|"activates"| PARP1([PARP1])
    MONOCYTES -->|"activates"| SIRT6([SIRT6])
    MONOCYTES -->|"activates"| T_CELL["/T CELL/"]
    MONOCYTES -->|"activates"| T_CELLS["/T CELLS/"]
    MONOCYTE["/MONOCYTE/"] -->|"interacts"| MONOCYTES
    MENINGITIS["MENINGITIS"] -->|"accumulates_in"| MONOCYTES
    MACROPHAGE["/MACROPHAGE/"] -->|"interacts"| MONOCYTES
    MACROPHAGES["/MACROPHAGES/"] -->|"interacts"| MONOCYTES

Outgoing (87)

Target	Relation	Type	Str
Lipid-Associated Macrophages	associated_with	cell_type	0.90
Pro-Inflammatory Signals	associated_with	process	0.85
Pro-inflammatory Signals	mediates	process	0.85
Retinal Neurodegeneration	exacerbates	phenotype	0.85
PARKINSON'S DISEASE	associated_with	disease	0.80
Tissue-Resident Macrophages	contributes_to	cell_type	0.80
Parkinson's Disease	associated_with	disease	0.75
ENDOTHELIAL CELLS	activates	cell_type	0.70
CELL DEATH	activates	phenotype	0.70
INFLAMMATION	interacts_with	phenotype	0.70
Parkinson's disease	associated_with	disease	0.70
CR1	treats	gene	0.65
NEUTROPHIL	accumulates_in	cell_type	0.65
NEUTROPHIL	interacts_with	cell_type	0.65
CLU	interacts_with	gene	0.65
STROKE	causes	disease	0.65
MACROPHAGES	produces	cell_type	0.65
BBB	interacts_with	brain_region	0.64
T CELL	contributes_to	cell_type	0.60
T CELLS	contributes_to	cell_type	0.60
PARP1	activates	gene	0.60
T CELL	activates	cell_type	0.60
T CELLS	activates	cell_type	0.60
SIRT6	activates	gene	0.60
CSF	expressed_in	phenotype	0.55
WHITE MATTER	co_discussed	entity	0.50
BLOOD_BRAIN_BARRIER	interacts_with	brain_region	0.50
FIBROBLASTS	expressed_in	concept	0.50
FIBROBLASTS	activates	concept	0.50
CELL MIGRATION	activates	concept	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
REMYELINATION	co_discussed	entity	0.50
DENDRITIC CELLS	expressed_in	concept	0.50
MS	co_discussed	entity	0.50
MYELINATION	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50
NECROPTOSIS	co_discussed	entity	0.50
SUBSTANTIA NIGRA	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
P2RY12	co_discussed	entity	0.50
SLEEP	co_discussed	entity	0.50
NEUTROPHILS	interacts_with	concept	0.50
PYROPTOSIS	co_discussed	entity	0.50
HEPATOCYTES	interacts_with	concept	0.50

Incoming (250)

Source	Relation	Type	Str
MACROPHAGES	inhibits	cell_type	0.95
LRRK2	expressed_in	protein	0.90
APOE	associated_with	gene	0.80
STAT3	activates	gene	0.70
RNA	associated_with	gene	0.70
NF-kB signaling	active_in	pathway	0.70
ENDOTHELIAL CELLS	interacts_with	cell_type	0.70
neuroinflammation	affects	disease	0.70
CX3CR1	promotes	gene	0.70
INFLAMMATION	activates	process	0.65
MACROPHAGE	sensitizes_to	cell_type	0.65
MACROPHAGES	sensitizes_to	cell_type	0.65
MONOCYTE	sensitizes_to	cell_type	0.65
MONOCYTE	increases	cell_type	0.65
MACROPHAGES	causes	cell_type	0.65
CCL2	activates	gene	0.65
MONOCYTE	accumulates_in	cell_type	0.65
MACROPHAGE	interacts_with	cell_type	0.65
MACROPHAGES	interacts_with	cell_type	0.65
MENINGITIS	accumulates_in	disease	0.65
MONOCYTE	causes	cell_type	0.65
ATHEROSCLEROSIS	interacts_with	disease	0.65
IL33	activates	gene	0.65
CR1	causes	gene	0.65
DIABETES	expressed_in	disease	0.65
DIABETES	causes	disease	0.65
ATHEROSCLEROSIS	reduces	disease	0.65
MONOCYTE	interacts_with	cell_type	0.65
PYCARD	associated_with	gene	0.60
LRRK2	activates	gene	0.60
SPTLC1	regulates	gene	0.60
SPTLC1	interacts_with	gene	0.60
SPTLC1	inhibits	gene	0.60
SPTLC1	expressed_in	gene	0.60
CXCL10	expressed_in	gene	0.60
BIN1	regulates	gene	0.60
APP	associated_with	gene	0.60
CD38	activates	gene	0.60
MACROPHAGE	activates	cell_type	0.60
MACROPHAGES	activates	cell_type	0.60
MONOCYTE	activates	cell_type	0.60
ENDOTHELIAL	interacts_with	cell_type	0.60
MICROGLIA	expressed_in	cell_type	0.60
LDLR	expressed_in	gene	0.60
CX3CR1	interacts_with	gene	0.60
C1QA	activates	gene	0.60
LRP1	activates	gene	0.60
C1QA	interacts_with	gene	0.60
LRP1	interacts_with	gene	0.60
NAD	associated_with	gene	0.60

Name	MONOCYTES
Key Genes/Proteins	AMYLOID, APP
Related Diseases	atherosclerosis, ATHEROSCLEROSIS

MONOCYTES

Understanding Entity Pages

Pathway Diagram

Outgoing (87)

Incoming (250)

Targeting Hypotheses (1)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)