concept

FLUOXETINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FLUOXETINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

19Outgoing

10Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FLUOXETINE
Key Genes/Proteins	BDNF, EGFR, SMPD1
Related Diseases	ANXIETY, CELL DEATH, NEUROGENESIS, NOREPINEPHRINE, SEROTONIN

Pathway Diagram

graph TD
    FLUOXETINE["FLUOXETINE"]
    FLUOXETINE -->|"inhibits"| SMPD1["SMPD1"]
    FLUOXETINE -->|"activates"| dural_Tregs["dural Tregs"]
    FLUOXETINE -->|"inhibits"| A1_reactive_astrocyte["A1 reactive astrocyte"]
    FLUOXETINE -.protects against.-> depressive_like_behavior["depressive-like behavior"]
    FLUOXETINE -->|"inhibits"| EGFR["EGFR"]
    FLUOXETINE -->|"activates"| NEURONS["NEURONS"]
    ENDOTHELIAL_CELLS["ENDOTHELIAL CELLS"] -->|"treats"| FLUOXETINE

Outgoing (19)

Target	Relation	Type	Str
dural Tregs	activates	cell_type	0.84
A1 reactive astrocyte	inhibits	cell_type	0.70
depressive-like behavior	protects_against	process	0.70
DENTATE GYRUS	treats	brain_region	0.70
NEUROGENESIS	treats	phenotype	0.70
EGFR	inhibits	gene	0.65
NEURONS	activates	cell_type	0.65
CA3	associated_with	brain_region	0.50
SMPD1	associated_with	gene	0.45
TEMOZOLOMIDE	associated_with	drug	0.45
SEROTONIN	associated_with	phenotype	0.45
CELL DEATH	associated_with	phenotype	0.45
EGFR	associated_with	gene	0.45
NOREPINEPHRINE	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
KETAMINE	associated_with	drug	0.45
BDNF	associated_with	gene	0.45
SERTRALINE	associated_with	drug	0.45
ANXIETY	associated_with	disease	0.45

Incoming (10)

Source	Relation	Type	Str
ENDOTHELIAL CELLS	treats	cell_type	0.65
SEROTONIN	inhibits	phenotype	0.65
DENTATE GYRUS	associated_with	brain_region	0.50
NEUROGENESIS	associated_with	phenotype	0.50
TEMOZOLOMIDE	associated_with	drug	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
EGFR	associated_with	gene	0.45
CELL DEATH	associated_with	phenotype	0.45
BDNF	associated_with	gene	0.45
ANXIETY	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity