concept

THBS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about THBS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

17Outgoing

20Incoming

0Experiments

0Debates

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💡 Concept Info

Name	THBS1
Key Genes/Proteins	C1QA, CCL20, CD36, CD38, CD4, extracellular vesicles
Related Pathways	ferroptosis

Pathway Diagram

graph TD
    THBS1[THBS1]
    THBS1 -->|component_of| Macrophage_Derived_Exosomes[Macrophage-Derived Exosomes]
    THBS1 -->|targets| Endothelial_Cells[Endothelial Cells]
    THBS1 -->|binds| OTUD5[OTUD5]
    THBS1 -->|correlates_with| MMP_9[MMP-9]
    THBS1 -->|induces| FERROPTOSIS[FERROPTOSIS]
    THBS1 -->|expressed in| macrophages[macrophages]
    THBS1 -->|regulates| Astrocyte_Function[Astrocyte Function]
    THBS1 -->|regulates| inhibitory_synapse_number[inhibitory synapse number]
    THBS1 -->|causes| endothelial_ferroptosis[endothelial ferroptosis]
    THBS1 -->|participates in| ferroptosis[ferroptosis]
    S100B[S100B] -.biomarker for.-> THBS1
    GPX4[GPX4] -->|activates| THBS1
    OTUD5 -->|activates| THBS1
    C1QA[C1QA] -->|activates| THBS1
    CCL20[CCL20] -->|activates| THBS1
    LRP1[LRP1] -->|activates| THBS1

Outgoing (17)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:THBS1	data_in	dataset_row	0.00
Ferroptosis	associated_with	process	0.95
Macrophage-Derived Exosomes	component_of	entity	0.95
OTUD5	binds	protein	0.90
Endothelial Cells	targets	cell_type	0.90
GPX4	associated_with	protein	0.85
macrophages	expressed_in	cell_type	0.80
MMP-9	correlates_with	biomarker	0.80
FERROPTOSIS	induces	process	0.80
Astrocyte Function	regulates	process	0.75
inhibitory synapse number	regulates	phenotype	0.70
endothelial cells	expressed_in	cell_type	0.60
endothelial ferroptosis	causes	process	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
ferroptosis	participates_in	pathway	0.60

Incoming (20)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:THBS1	data_in	dataset_row	0.00
extracellular vesicles	associated_with	gene	0.70
GBM	associated_with	gene	0.60
S100B	biomarker_for	gene	0.60
GPX4	activates	gene	0.60
OTUD5	activates	gene	0.60
GPX4	inhibits	gene	0.60
OTUD5	inhibits	gene	0.60
GPX4	regulates	gene	0.60
OTUD5	regulates	gene	0.60
C1QA	activates	gene	0.60
CCL20	activates	gene	0.60
LRP1	activates	gene	0.60
RNA	activates	gene	0.60
CD36	activates	gene	0.60
CD38	activates	gene	0.60
CD4	activates	gene	0.60
MS4A6A	activates	gene	0.60
PECAM1	activates	gene	0.60
PTGER2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning THBS1 in their description or question text

No additional research found