concept

DENDRITIC SPINE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DENDRITIC SPINE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections

1Hypotheses

0Analyses

44Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	DENDRITIC SPINE
Key Genes/Proteins	amyotrophic lateral sclerosis, BDNF

Pathway Diagram

graph TD
    DENDRITIC_SPINE["DENDRITIC SPINE"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| DENDRITIC_SPINE
    FYN["FYN"] -->|"regulates"| DENDRITIC_SPINE
    JUN["JUN"] -->|"regulates"| DENDRITIC_SPINE
    SRC["SRC"] -->|"regulates"| DENDRITIC_SPINE
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| DENDRITIC_SPINE
    DEPRESSION["DEPRESSION"] -->|"regulates"| DENDRITIC_SPINE
    DAB1["DAB1"] -->|"regulates"| DENDRITIC_SPINE
    REELIN["REELIN"] -->|"regulates"| DENDRITIC_SPINE
    EPILEPSY["EPILEPSY"] -->|"regulates"| DENDRITIC_SPINE
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| DENDRITIC_SPINE
    COMPLEMENT["COMPLEMENT"] -->|"activates"| DENDRITIC_SPINE
    NF__B["NF-KappaB"] -->|"activates"| DENDRITIC_SPINE

Outgoing (44)

Target	Relation	Type	Str
glutamatergic synapse	associated_with	process	0.90
PREFRONTAL	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
ULK1	co_discussed	entity	0.50
MS	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
DEPRESSION	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
GAP43	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
VEGF	co_discussed	entity	0.50
PINK1	co_discussed	entity	0.50
PYROPTOSIS	co_discussed	entity	0.50
FTD	co_discussed	entity	0.50
GABA	co_discussed	entity	0.50
GLUCOSE METABOLISM	co_discussed	entity	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50
PSD95	co_discussed	entity	0.50
ERK	co_discussed	entity	0.50
STRIATUM	co_discussed	entity	0.50
GFAP	co_discussed	entity	0.50
HISTONE	co_discussed	entity	0.50
VCP	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
PYRAMIDAL	co_discussed	entity	0.50
CENTRAL NERVOUS SYSTEM	interacts_with	concept	0.50
LONG-TERM POTENTIATION	co_discussed	entity	0.50
NMDA	co_discussed	entity	0.50
SOD1	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
GLUTAMATE	co_discussed	entity	0.50
GLUTAMATERGIC	co_discussed	entity	0.50
GRANULE CELL	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
SCHIZOPHRENIA	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
OLIGODENDROCYTES	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50

Incoming (194)

Source	Relation	Type	Str
uridine	promotes	compound	0.90
Quinolinic Acid	inhibits	compound	0.85
AMYLOID-BETA	inhibits	gene	0.60
SRC	regulates	gene	0.60
DAB1	regulates	gene	0.60
REELIN	regulates	gene	0.60
C1Q	activates	gene	0.60
C1QA	activates	gene	0.60
SYNPO	associated_with	gene	0.60
ARHGEF7	regulates	gene	0.60
RAC1	regulates	gene	0.60
APP	inhibits	gene	0.60
HDAC3	inhibits	gene	0.60
EPILEPSY	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
FYN	regulates	gene	0.60
JUN	regulates	gene	0.60
ASTROCYTE	activates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
CR1	associated_with	gene	0.60
APP	associated_with	gene	0.60
IBA1	associated_with	gene	0.60
HDAC4	regulates	gene	0.60
MEF2C	regulates	gene	0.60
DEPRESSION	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
DNA	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
TAU	associated_with	gene	0.60
GENES	regulates	gene	0.60
SIK3	regulates	gene	0.60
HUNTINGTON	regulates	gene	0.60
HUNTINGTON'S DISEASE	regulates	gene	0.60
AND	causes	gene	0.60
ALZHEIMER	activates	gene	0.60
GENES	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
SYNAPSE	activates	gene	0.60
AND	regulates	gene	0.60
APOER2	regulates	gene	0.60
AND	activates	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Neuronal TET1 Upregulation Reactivates Immediate-Early Genes	0.640	neurodegeneration	epigenetic reprogramming aging neurons

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DENDRITIC SPINE in their description or question text

No additional research found