concept

TNF-ALPHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNF-ALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

165Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TNF-ALPHA
Key Genes/Proteins	ACTB, Actin, AGING, AIF1, AND, ANG
Related Diseases	Addiction, Aging, Als, ALS
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    TNF_ALPHA["TNF-ALPHA"]
    style TNF_ALPHA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    TNF_ALPHA -->|"activates"| apoptosis(apoptosis)
    TNF_ALPHA -->|"involved_in"| Neuroinflammation["Neuroinflammation"]
    TNF_ALPHA -->|"upregulates"| Oxidative_Stress["Oxidative Stress"]
    TNF_ALPHA -.->|"inhibits"| Depression["Depression"]
    TNF_ALPHA -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    TNF_ALPHA -->|"regulates"| Parkinson["Parkinson"]
    TNF_ALPHA -.->|"inhibits"| Aging["Aging"]
    TNF_ALPHA -->|"regulates"| Tumor["Tumor"]
    TNF_ALPHA -.->|"inhibits"| ALS["ALS"]
    TNF_ALPHA -.->|"inhibits"| Inflammation["Inflammation"]
    ADAM17([ADAM17]) -->|"activates"| TNF_ALPHA
    Etanercept{"Etanercept"} -.->|"inhibits"| TNF_ALPHA
    etanercept{"etanercept"} -.->|"inhibits"| TNF_ALPHA
    CD40["CD40"] -->|"upregulates"| TNF_ALPHA
    AIF1([AIF1]) -->|"regulates"| TNF_ALPHA
    ATG5([ATG5]) -->|"regulates"| TNF_ALPHA
    ATG7([ATG7]) -->|"regulates"| TNF_ALPHA
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| TNF_ALPHA
    BECN1([BECN1]) -->|"regulates"| TNF_ALPHA
    CASP1([CASP1]) -->|"regulates"| TNF_ALPHA

Outgoing (87)

Target	Relation	Type	Str
Neuroinflammation	involved_in	process	0.90
apoptosis	activates	phenotype	0.90
Neuroinflammation	mediates	process	0.85
Temporal Lobe Epilepsy	contributes_to	disease	0.80
Oxidative Stress	upregulates	process	0.80
INTRACEREBRAL HEMORRHAGE	associated_with	disease	0.80
Als	activates	disease	0.65
Parkinson	regulates	disease	0.65
Aging	inhibits	disease	0.65
Tumor	regulates	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Depression	inhibits	disease	0.65
ALS	activates	disease	0.65
Addiction	associated_with	disease	0.65
CRHR1	associated_with	gene	0.60
JUN	associated_with	gene	0.60
DNA	associated_with	gene	0.60
CRHBP	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
Epigenetic	associated_with	pathway	0.60
MAP1LC3B	regulates	gene	0.60
PYCARD	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
NR3C1	associated_with	gene	0.60
IL1B	regulates	gene	0.60
Hypersexual Disorder	associated_with	disease	0.60
GENES	associated_with	gene	0.60
RIPK1	activates	gene	0.60
Ubiquitin	activates	protein	0.60
RNA	activates	gene	0.60
GAIN	activates	gene	0.60
ANG	activates	gene	0.60
Apoptosis	activates	pathway	0.60
ATF3	regulates	gene	0.60
PDGFRB	regulates	gene	0.60
Nfkb	activates	protein	0.60
Pdgf	regulates	protein	0.60
Rb	regulates	protein	0.60
NFKB1	activates	gene	0.60
DEPRESSION	inhibits	gene	0.60
App	associated_with	protein	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	regulates	gene	0.60
ACTB	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NLRP3	regulates	gene	0.60
AND	regulates	gene	0.60

Incoming (78)

Source	Relation	Type	Str
ADAM17	activates	protein	0.90
Etanercept	inhibits	drug	0.85
etanercept	inhibits	drug	0.85
gingipain cysteine proteases	degrades	protein	0.80
Celastrol	suppresses	gene	0.80
ABETA	upregulates	protein	0.80
ANTHOCYANINS	inhibits	compound	0.80
sesquiterpenoids	downregulates	compound	0.75
AIF1	regulates	gene	0.65
ATG5	regulates	gene	0.65
ATG7	regulates	gene	0.65
BECN1	regulates	gene	0.65
CASP1	regulates	gene	0.65
DOPAMINERGIC	regulates	cell_type	0.65
GFAP	regulates	gene	0.65
IBA1	regulates	gene	0.65
IL1B	regulates	gene	0.65
IL6	regulates	gene	0.65
NEURON	regulates	cell_type	0.65
NEURONS	regulates	cell_type	0.65
NLRP3	expressed_in	gene	0.65
PARKIN	expressed_in	gene	0.65
TH	regulates	gene	0.65
PARKINSON	expressed_in	disease	0.65
PDGFRB	regulates	gene	0.60
FADD	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
TNF	activates	gene	0.60
GAIN	activates	gene	0.60
ANG	activates	gene	0.60
NFKB1	activates	gene	0.60
ATF3	regulates	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
TNF	inhibits	gene	0.60
CRHR1	associated_with	gene	0.60
DEPRESSION	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
UBIQUITIN	regulates	gene	0.60
PYCARD	regulates	gene	0.60
NLR	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
GFP	inhibits	gene	0.60
SQSTM1	regulates	gene	0.60
CRHBP	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
JUN	associated_with	gene	0.60
CYLD	activates	gene	0.60
RIPK1	activates	gene	0.60
SMAC	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TNF-ALPHA in their description or question text

No additional research found