concept

CELASTROL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELASTROL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

20Connections

0Hypotheses

1Analyses

18Outgoing

2Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CELASTROL

Pathway Diagram

graph TD
    CELASTROL[CELASTROL]
    CELASTROL -->|binds_to| sorcin[sorcin]
    CELASTROL -->|activates| CASP3[CASP3]
    CELASTROL -->|activates| GSDME[GSDME]
    CELASTROL -->|promotes| ROS[ROS]
    CELASTROL -->|promotes| Reactive_Oxygen_Species[Reactive Oxygen Species]
    CELASTROL -->|promotes| mitochondrial_ROS_accumulation[mitochondrial ROS accumulation]
    CELASTROL -->|promotes| ferroptosis[ferroptosis]
    CELASTROL -->|upregulates| CALR[CALR]
    CELASTROL -->|treats| Cancer[Cancer]
    Zwitterionic_Nanogels[Zwitterionic Nanogels] -->|transports| CELASTROL

Outgoing (18)

Target	Relation	Type	Str
CASP3	activates	gene	0.95
ROS	promotes	process	0.95
GSDME	activates	gene	0.95
sorcin	binds_to	protein	0.95
Pyroptosis	associated_with	process	0.95
Reactive Oxygen Species	promotes	process	0.95
mitochondrial ROS accumulation	promotes	process	0.92
ferroptosis	promotes	process	0.90
CALR	upregulates	gene	0.85
Cancer	treats	disease	0.85
Cancer	treats	disease	0.85
Atp Secretion	associated_with	biomarker	0.85
Ldh Release	associated_with	biomarker	0.85
TNF-ALPHA	suppresses	protein	0.80
M1 MICROGLIA	suppresses	cell_type	0.70
INTRACEREBRAL HEMORRHAGE	associated_with	disease	0.70
TFEB-mediated tau clearance	causes (enhances TFEB activity to promote selective cleara)	mechanism	0.60
NECROPTOSIS	modulates	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
zwitterionic nanogels	associated_with	compound	0.92
Zwitterionic Nanogels	transports	compound	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.697

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted TFEB's role in mitochondrial-lysosomal coupling but could

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning CELASTROL in their description or question text

No additional research found