concept

CA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

2Hypotheses

1Analyses

16Outgoing

50Incoming

10Experiments

1Debates

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💡 Concept Info

Name	CA3
Key Genes/Proteins	APP, BCL2, BDNF
Related Diseases	AGING, ALZHEIMER'S DISEASE, APOPTOSIS, AUTOPHAGY, COGNITIVE DECLINE
Linked Hypotheses	2 hypotheses

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CA3["CA3"]
    CA3 -->|"contributes to"| HIPPOCAMPUS["HIPPOCAMPUS"]
    CA3 -->|"regulates"| INTERNEURON["INTERNEURON"]
    CA3 -->|"regulates"| NEURON["NEURON"]
    CA3 -->|"interacts"| PYRAMIDAL["PYRAMIDAL"]
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"contributes to"| CA3
    DNA["DNA"] -->|"expressed in"| CA3
    SP1["SP1"] -->|"expressed in"| CA3
    ATP2A3["ATP2A3"] -->|"expressed in"| CA3
    SP3["SP3"] -->|"expressed in"| CA3
    CANCER["CANCER"] -->|"expressed in"| CA3
    ATP["ATP"] -->|"expressed in"| CA3
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"expressed in"| CA3

Outgoing (16)

Target	Relation	Type	Str
INTERNEURONS	activates	cell_type	0.70
CA1	regulates	brain_region	0.70
INTERNEURONS	targets	cell_type	0.65
DENTATE GYRUS	regulates	brain_region	0.65
HIPPOCAMPUS	interacts_with	brain_region	0.65
BCL2	implicated_in	gene	0.60
HIPPOCAMPUS	contributes_to	brain_region	0.60
INTERNEURON	regulates	cell_type	0.60
NEURON	regulates	cell_type	0.60
PYRAMIDAL	interacts_with	cell_type	0.60
CORTEX	co_discussed	brain_region	0.40
DENTATE GYRUS	co_discussed	brain_region	0.40
NEURON	co_discussed	cell_type	0.40
NEURONS	co_discussed	cell_type	0.40
PYRAMIDAL	co_discussed	cell_type	0.40
HIPPOCAMPUS	co_discussed	brain_region	0.40

Incoming (86)

Source	Relation	Type	Str
HIPPOCAMPUS	causes	brain_region	0.65
OXIDATIVE STRESS	expressed_in	gene	0.55
NEURODEGENERATION	expressed_in	gene	0.55
P53	expressed_in	gene	0.55
CANCER	expressed_in	gene	0.55
IBA1	expressed_in	gene	0.55
DNA	expressed_in	gene	0.55
ATP	expressed_in	gene	0.55
SLEEP-WAKE CYCLE	expressed_in	gene	0.55
NEUROINFLAMMATION	expressed_in	gene	0.55
BLOOD-BRAIN BARRIER DYSFUNCTION	expressed_in	gene	0.55
ALZHEIMER	expressed_in	gene	0.55
BRAIN INJURY	expressed_in	gene	0.55
ALZHEIMER'S DISEASE	expressed_in	gene	0.55
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.55
GENES	expressed_in	gene	0.55
RNA	expressed_in	gene	0.55
AMYLOID	expressed_in	gene	0.55
AXON	expressed_in	gene	0.55
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.55
OLIGODENDROCYTE	expressed_in	gene	0.55
ABCA4	expressed_in	gene	0.55
EXERCISE	expressed_in	gene	0.55
MICROGLIA ACTIVATION	expressed_in	gene	0.55
ASTROCYTES	expressed_in	gene	0.55
MICROGLIA	expressed_in	gene	0.55
SYNAPSE	expressed_in	gene	0.55
DEMENTIA	expressed_in	gene	0.55
ARC	expressed_in	gene	0.55
CD4	expressed_in	gene	0.55
IFNG	expressed_in	gene	0.55
AND	expressed_in	gene	0.55
SP1	expressed_in	gene	0.55
ATP2A3	expressed_in	gene	0.55
SP3	expressed_in	gene	0.55
BAX	expressed_in	gene	0.55
SST	expressed_in	gene	0.55
TAU	expressed_in	gene	0.55
GAIN	expressed_in	gene	0.55
TNFRSF13C	expressed_in	gene	0.55
ATXN3	expressed_in	gene	0.55
SCA3	expressed_in	gene	0.55
ABCA7	expressed_in	gene	0.55
ABCA1	expressed_in	gene	0.55
CD8	expressed_in	gene	0.55
Neurodegeneration	associated_with	disease	0.50
ALS	associated_with	disease	0.50
Cancer	associated_with	disease	0.50
SYNAPTIC TRANSMISSION	associated_with	phenotype	0.50
FLUOXETINE	associated_with	drug	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hippocampal CA3-CA1 synaptic rescue via DHHC2-mediated PSD95	0.861	Alzheimer's disease	Circuit-level neural dynamics in neurode
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna	0.820	Alzheimer's disease	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 67 hypotheses Top: 1.000

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Spp1 knockout prevents synaptic loss in AD mouse models	validation	Alzheimer's disease	0.900	0.00	Spp1 knockout AD mouse models	proposed	N/A
Synaptic plasticity and protein expression analysis in mPFC	exploratory	insomnia-anxiety comorbidity	0.850	0.00	mPFC brain slices from PCPA-tr	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Positive Indiv	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$6,550,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Animal Model Comparison for Neurodegenerative Disease Therapeutics	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Antidepressant effects of combined eucommia-gastrodia extract via modulation of [PMID:41921863]	Xue L, Pan Z, Liu Y, Gan Q, Liu D, Liu D	Brain research bulletin	2026
Complementary mechanisms of high-carbohydrate diets and ketogenic diets restore [PMID:41475465]	Kwon H, Seo DS, Ahmad Y, Park S, Yoo J,	The Journal of nutritional bio	2026
TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate micr [PMID:41922794]	Shi X, Cai SZ, Chai JL, Xu CY, Zhou BY,	Molecular psychiatry	2026
The Potential Functions and Beneficial Effects of Melatonin on Cognitive Impairm [PMID:41917799]	Li XY, Cheng YZ, Zhang YM, Hu F, Fang SK	Brain and behavior	2026
Biomarkers for Alzheimer's disease across diverse biological domains: an umbrell [PMID:40680830]	Kang J, Son Y, Yim Y, Cho H, Kim J et al	J Adv Res	2026
Nanotherapeutic potential of Baicalein-encapsulated hUC-MSC exosomes in Alzheime [PMID:41370943]	Xu J, He Z, Pan Y, Cao B, Chen G	Biomater Adv	2026
Epigenetic mechanisms and therapeutic innovations in chronic pain-associated neu [PMID:41554641]	Zhang K, Zhu S, Xing N, Zhou Z, Chen J e	Br J Pharmacol	2026
Postbiotics and the gut-brain axis: A mechanistic review on modulating neuroinfl [PMID:41570486]	Lahariya R, Anand G, Kumari B, Priyadars	J Neuroimmunol	2026
miRNA-206 in muscle and central nervous system crosstalk during exercise: A doub [PMID:41571168]	Malvandi AM, Gerosa L, Maroni P, Orlando	Neurosci Biobehav Rev	2026
Experts' narrative review "Mastication, Hippocampal Structure Changes and Cognit [PMID:41576846]	Piancino MG	Arch Oral Biol	2026
Plant-derived bioactive compounds modulate the gut microbiota in Alzheimer's dis [PMID:41678917]	Xue D, Hu X, Li R, Sun T, Qian S et al.	Phytomedicine	2026
Dysregulation of Drp1 and Mfn2 is associated with reduced PSD-95, synaptophysin, [PMID:41932483]	Alfateh M, Vasconcelos C, Choker AH, Moh	Int J Biol Macromol	2026
AICAR improves depression-like behaviors and is associated with hippocampal AMPK [PMID:41932583]	Takahashi K, Kurokawa K, Kawaguchi R, Ta	Neurochem Int	2026
Human umbilical cord mesenchymal stem cells therapy for Alzheimer's disease: a s [PMID:41847685]	Si C, Ma L, Ding W, Tian Y, Zhang J, Cao	Frontiers in neurology	2026
Cannabidiol and pBDNF Cotreatment Attenuates Pathological Symptoms and Improves [PMID:41924980]	Chaulagain B, Gothwal A, Mahanta AK, Jar	ACS chemical neuroscience	2026
Advances and Therapeutic Potential of Anthraquinone Compounds in Neurodegenerati [PMID:41868184]	Liu Z, Zhang H, Wan B, Yin S, Yue R	Drug design, development and t	2026
Modulation of mitochondrial quality by exercise mimetics: A potential strategy f [PMID:41804756]	Ke Z, Wang B, Liang R	Journal of Alzheimer's disease	2026
Neurotransmitter dysregulation in depression, anxiety, and suicidality: From syn [PMID:41924767]	K S V ABG, Verma AK, A SS, Sinha SS, Boy	Psychiatry research	2026
Hippocampal neural circuit mechanisms in Alzheimer's disease revealed by viral-g [PMID:41082949]	["Ye Q", "Gast G", "Holmes T", "Xu X"]	Neurobiology of disease	2025
Therapeutic Potential of Natural Compounds for Brain Ischemia-Reperfusion Injury [PMID:41007298]	["Yoo K", "Won M", "Ahn J", "Park J"]	Biology	2025

Debates (1)

Multi-agent debates referencing this entity

Analyze circuit-level changes in neurodegeneration using Allen Institute Neural

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning CA3 in their description or question text

No additional research found

CA3

Understanding Entity Pages

Wiki Pages (19)

Dentate Mossy Fiber to CA3 Synaptic Neurons

Hippocampal CA3 Pyramidal Neurons in Epilepsy

Hippocampal CA3 Neurons

SCA3 — ATXN3 (Ataxin-3)

CA3 Pyramidal Cells

CA3 Pyramidal Neurons

Hippocampal CA3 Pyramidal Neurons (Expanded)

Hippocampal CA3 Pyramidal Neurons in Memory

Hippocampal CA3 Pyramidal Neurons

CA3 Mossy Cells

Hippocampal CA3 Pyramidal Cells

Hippocampal CA3 Pyramidal Neurons in Neurodegeneration

Hippocampal CA3 Stratified Interneurons

Hippocampal CA3 Mossy Cells

Hippocampal CA3 Pyramidal Neurons in Alzheimer's Disease