concept

INTERNEURONS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERNEURONS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

362Connections

23Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INTERNEURONS
Key Genes/Proteins	AMYLOID, APP, arnt2
Related Diseases	ACETYLCHOLINE, ALZHEIMER'S DISEASE, ASTROGLIOSIS, AUTISM

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interneurons

cell · 811 words

→

Pathway Diagram

graph TD
    INTERNEURONS["INTERNEURONS"]
    INTERNEURONS -->|"interacts"| NEURON["NEURON"]
    INTERNEURONS -->|"promotes"| NEURONS["NEURONS"]
    CORTEX["CORTEX"] -->|"expressed in"| INTERNEURONS
    INTERNEURON["INTERNEURON"] -->|"promotes"| INTERNEURONS
    HIPPOCAMPUS["HIPPOCAMPUS"] -->|"expressed in"| INTERNEURONS

Outgoing (111)

Target	Relation	Type	Str
NEURON	interacts_with	cell_type	0.95
Neuronal Excitation-Inhibition Balance	modulates	process	0.90
ACETYLCHOLINE	inhibits	phenotype	0.70
SYNAPTIC PLASTICITY	activates	phenotype	0.70
SYNAPTIC PLASTICITY	protects_against	phenotype	0.70
SYNAPTIC PLASTICITY	produces	phenotype	0.70
SYNAPTIC PLASTICITY	inhibits	phenotype	0.70
NEURON	promotes	cell_type	0.65
NEURONS	promotes	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
NEURON	inhibits	cell_type	0.65
SEPSIS	regulates	disease	0.65
NEURONS	expressed_in	cell_type	0.60
NEURON	causes	cell_type	0.60
NEURONS	causes	cell_type	0.60
NEURON	protects_against	cell_type	0.60
NEURONS	protects_against	cell_type	0.60
NEURON	regulates	cell_type	0.60
NEURONS	regulates	cell_type	0.60
NEURON	expressed_in	cell_type	0.60
PYRAMIDAL	causes	cell_type	0.60
NEURONS	activates	cell_type	0.60
NEURONS	targets	cell_type	0.60
NEURON	targets	cell_type	0.60
NEURON	activates	cell_type	0.60
SYN1	expressed_in	gene	0.60
PYRAMIDAL	regulates	cell_type	0.60
THALAMUS	promotes	brain_region	0.60
PREFRONTAL	inhibits	brain_region	0.60
NEURON	contributes_to	cell_type	0.60
NEURONS	contributes_to	cell_type	0.60
NEURON	impairs	cell_type	0.60
NEURONS	impairs	cell_type	0.60
PREFRONTAL	activates	brain_region	0.60
NEURON	biomarker_for	cell_type	0.60
NEURONS	biomarker_for	cell_type	0.60
NEURON	associated_with	cell_type	0.60
NEURONS	associated_with	cell_type	0.60
NEURODEGENERATION	biomarker_for	disease	0.60
CORTEX	participates_in	brain_region	0.55
VALPROATE	associated_with	drug	0.50
CA1	associated_with	brain_region	0.50
MITOCHONDRIAL DYSFUNCTION	co_discussed	entity	0.50
NEUROINFLAMMATION	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50
ISCHEMIA	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
STING	co_discussed	entity	0.50

Incoming (251)

Source	Relation	Type	Str
CORTEX	expressed_in	brain_region	0.95
SST	regulates	gene	0.90
schizophrenia	affects	disease	0.90
SST	expressed_in	gene	0.80
SST	interacts_with	gene	0.80
PVALB	regulates	gene	0.80
autism	affects	disease	0.80
SST	associated_with	gene	0.80
SST	inhibits	gene	0.70
BDNF	regulates	gene	0.70
axon	found_in	organelle	0.70
neuroinflammation	affects	disease	0.70
PVALB	expressed_in	gene	0.70
PVALB	modulates	gene	0.70
neurodegeneration	affects	disease	0.70
PVALB	associated_with	gene	0.70
MICROGLIAL ACTIVATION	causes	phenotype	0.70
Alzheimer's disease	affects	disease	0.70
CA3	activates	brain_region	0.70
synaptic plasticity	active_in	pathway	0.70
epilepsy	affects	disease	0.70
NEURONS	produces	cell_type	0.70
GDNF	produces	gene	0.65
CA3	targets	brain_region	0.65
NEUROGENESIS	produces	phenotype	0.65
BDNF	targets	gene	0.65
GABA	produces	phenotype	0.65
CORTEX	targets	brain_region	0.65
LRRK2	inhibits	gene	0.65
INTERNEURON	promotes	cell_type	0.65
CHROMATIN REMODELING	regulates	phenotype	0.65
INTERNEURON	reduces	cell_type	0.65
VALPROATE	modifies	drug	0.65
HIPPOCAMPUS	expressed_in	brain_region	0.65
INTERNEURON	activates	cell_type	0.60
C3	regulates	gene	0.60
FRONTAL	inhibits	brain_region	0.60
CORTEX	contributes_to	brain_region	0.60
INTERNEURON	contributes_to	cell_type	0.60
C3	inhibits	gene	0.60
INTERNEURON	impairs	cell_type	0.60
CORTEX	biomarker_for	brain_region	0.60
GABAERGIC	expressed_in	cell_type	0.60
aging	affects	disease	0.60
CHOLINERGIC	expressed_in	cell_type	0.60
CHOLINERGIC	contributes_to	cell_type	0.60
DRD2	activates	gene	0.60
Parkinson's disease	affects	disease	0.60
DRD2	regulates	gene	0.60
BDNF	activates	gene	0.60

Targeting Hypotheses (23)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop transcranial focused ultrasound targeting EC-II	0.948	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore	0.944	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting CA1 PV interneurons	0.927	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting EC-II	0.922	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur	0.900	Alzheimer's disease	Circuit-level neural dynamics in neurode

Closed-loop tACS targeting EC-II SST interneurons to block t	0.896	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to enhance	0.867	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II PV interneurons to suppress	0.857	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II parvalbumin interneurons to	0.831	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound to restore hippo	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time gamma-guided transcranial focused ultrasound targe	0.827	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting CA1 PV	0.797	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.784	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II somatostatin interneurons t	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Closed-loop transcranial focused ultrasound targeting entorh	0.564	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time closed-loop transcranial focused ultrasound target	0.559	Alzheimer's disease	Circuit-level neural dynamics in neurode
Optogenetic restoration of hippocampal gamma oscillations vi	0.555	Alzheimer's disease	Circuit-level neural dynamics in neurode
Real-time closed-loop transcranial focused ultrasound target	0.542	Alzheimer's disease	Circuit-level neural dynamics in neurode
Gamma-Entrained PV Interneurons Enable p-tau217-Guided Preci	0.536	molecular neurobiology	View
APOE4 astrocytes fail to supply sufficient cholesterol to pa	0.500	neuroscience	APOE4-driven lipid metabolism dysregulat
Gamma-Entrained PV Interneurons Enable Precision p-tau217-Gu	0.461	molecular neurobiology	View
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity