concept

CALCIUM HOMEOSTASIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCIUM HOMEOSTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

1Analyses

12Outgoing

31Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	CALCIUM HOMEOSTASIS

Pathway Diagram

graph TD
    CALCIUM_HOMEOSTASIS["CALCIUM HOMEOSTASIS"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neurite_Outgrowth["Neurite Outgrowth"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptogenesis["Synaptogenesis"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Plasticity["Synaptic Plasticity"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neuronal_Survival["Neuronal Survival"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Dysfunction["Synaptic Dysfunction"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Neuronal_Degeneration["Neuronal Degeneration"]
    CALCIUM_HOMEOSTASIS -->|"regulates"| Synaptic_Transmission["Synaptic Transmission"]
    CALCIUM_HOMEOSTASIS -->|"component_of"| Lysosomal_Functions["Lysosomal Functions"]
    Mitochondria["Mitochondria"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    SERCA3["SERCA3"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    PSEN1["PSEN1"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    TRPML1["TRPML1"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    SNCA["SNCA"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    HTT["HTT"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    Energy_Metabolism["Energy Metabolism"] -->|"regulates"| CALCIUM_HOMEOSTASIS
    ER_Mitochondria_Contacts["ER-Mitochondria Contacts"] -->|"regulates"| CALCIUM_HOMEOSTASIS

Outgoing (12)

Target	Relation	Type	Str
Synaptic Plasticity	regulates	process	0.95
Neurite Outgrowth	regulates	process	0.95
Synaptogenesis	regulates	process	0.95
Neuronal Survival	regulates	process	0.95
Synaptic Dysfunction	regulates	phenotype	0.90
Neuronal Degeneration	regulates	phenotype	0.90
Synaptic Transmission	regulates	process	0.90
Lysosomal Functions	component_of	mechanism	0.85
AUTOPHAGY	regulates	process	0.85
AMPK	activates	gene	0.85
Frailty	associated_with	phenotype	0.80
Aging	involved_in	process	0.80

Incoming (31)

Source	Relation	Type	Str
Mitochondria	involved_in	cell_type	0.95
Mitochondria	regulates	cell_type	0.95
SERCA3	regulates	protein	0.95
TRPML1	regulates	protein	0.90
PSEN1	regulates	gene	0.90
Amyloid Beta-Peptide	associated_with	compound	0.90
MCOLN1	regulates	gene	0.90
Oxidative Stress	associated_with	process	0.90
Basal Ganglia Calcifications	associated_with	disease	0.88
MITOCHONDRIA	regulates	cell_type	0.88
Er-Mitochondria Contacts	regulates	process	0.85
ER-Mitochondria Contacts	regulates	process	0.85
CACNA1G	regulates	gene	0.85
Aging	involved_in	process	0.85
ATP2A3	involved_in	gene	0.85
ion pumps	associated_with	protein	0.85
Oxidative Stress	inhibits	process	0.85
HTT	regulates	gene	0.85
Endoplasmic Reticulum	regulates	organelle	0.85
SNCA	regulates	gene	0.85
endoplasmic reticulum	involved_in	cell_type	0.85
Energy Metabolism	regulates	process	0.85
Urolithin A	modulates	compound	0.80
ANXA11	regulates	gene	0.80
SNCA	modulates	gene	0.80
AMYLOID-BETA	inhibits	protein	0.80
SNCA	inhibits	protein	0.80
amyloid-beta	associated_with	compound	0.80
SOD1	regulates	protein	0.75
APOE	regulates	protein	0.75
ATP2B1	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does tau aggregation specifically cause PS externalization in living cells versu

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate identified a critical gap in understanding whether PS exposure is tau

closed · Rounds: 4 · Score: 0.44 · 2026-04-21

Related Research

Hypotheses and analyses mentioning CALCIUM HOMEOSTASIS in their description or question text

No additional research found