protein

GABA-B RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABA-B RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

1Outgoing

2Incoming

0Experiments

0Debates

Summary

The metabotropic GABA-B receptor is a GPCR that mediates slow inhibitory neurotransmission; involved in epilepsy, addiction, and being explored for neurodegenerative diseases

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🔬 Protein Info

Gene Symbol	GABA
Full Name	B RECEPTOR
Chromosome	12p12.3
Function	is a hallmark of neurodegeneration.
Primary Expression	hippocampus, cortex, cerebellum, thalamus, hypothalamus
Amino Acids	602 aa
Exons	14
Pathways	GABAergic Signaling
GeneCards	GABA
Human Protein Atlas	GABA
Associated Diseases	Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	rapamycin
Interactions	ABCA7, ACTB, Actin, Akt, AKT, AKT1
KG Connections	1381 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    GABA["GABA"]
    LC3B["LC3B"]
    GABA -->|"regulates"| LC3B
    ALS["ALS"]
    GABA -->|"activates"| ALS
    MTORC1["MTORC1"]
    GABA -->|"activates"| MTORC1
    Epigenetic["Epigenetic"]
    GABA -->|"regulates"| Epigenetic
    RB1["RB1"]
    GABA -->|"interacts_with"| RB1
    Actin["Actin"]
    GABA -->|"interacts_with"| Actin
    Microglia["Microglia"]
    GABA -->|"expressed_in"| Microglia
    CTSD["CTSD"]
    GABA -->|"associated_with"| CTSD
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    GABA -->|"co_discussed"| FRONTOTEMPORAL_DEMENTIA
    PIK3C3["PIK3C3"]
    GABA -->|"regulates"| PIK3C3
    MICROGLIA["MICROGLIA"]
    GABA -->|"co_discussed"| MICROGLIA
    lysosome["lysosome"]
    GABA -->|"inhibits"| lysosome
    style GABA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style LC3B fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MTORC1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Epigenetic fill:#1b5e20,stroke:#333,stroke-width:1px,color:#e0e0e0
    style RB1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Actin fill:#4a1a6b,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Microglia fill:#01579b,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CTSD fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style FRONTOTEMPORAL_DEMENTIA fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style PIK3C3 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MICROGLIA fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style lysosome fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
Synaptic Transmission	regulates	process	0.85

Incoming (2)

Source	Relation	Type	Str
Phaclofen	targets	drug	0.95
depression	involves	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABA-B RECEPTOR in their description or question text

No additional research found