gene

CPLX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CPLX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

13Outgoing

2Incoming

0Experiments

0Debates

Summary

CPLX2 — Complexin 2

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🧬 Gene Info

Gene Symbol	CPLX2
Full Name	Complexin 2
Chromosome	5q31.2
Function	Complexin 2 is a cytosolic protein that regulates SNARE complex assembly
Amino Acids	150 aa
UniProt ID	O75178
NCBI Gene ID	10857
Ensembl ID	ENSG00000128487
OMIM	605738
GeneCards	CPLX2
Human Protein Atlas	CPLX2
Associated Diseases	Alzheimer, neurodegeneration
Interactions	BDNF, DNM1L, ICAM1, PINK1, TFAM, TNF
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CPLX2 — AlphaFold O75178 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CPLX2 — Complexin 2

gene · 917 words

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Pathway Diagram

flowchart TD
    N0["CPLX2"]
    N1["neurodegeneration"]
    N0 -->|"associated with"| N1
    N2["Alzheimer"]
    N0 -->|"associated with"| N2
    N3["DNM1L"]
    N0 -->|"co expressed with"| N3
    N4["GPX1"]
    N0 -->|"co expressed with"| N4
    N5["BDNF"]
    N5 -->|"co expressed with"| N0
    N0 -->|"implicated in"| N1

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene

Outgoing (13)

Target	Relation	Type	Str
synaptic plasticity	involved_in	process	0.80
synaptic transmission	involved_in	process	0.75
neurodegeneration	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
oxidative stress response	participates_in	pathway	0.60
DNM1L	activates	gene	0.60
ICAM1	activates	gene	0.60
PINK1	activates	gene	0.60
TFAM	activates	gene	0.60
TNF	activates	gene	0.60
mitochondrial function	participates_in	pathway	0.60
DNM1L	co_expressed_with	gene	0.50
GPX1	co_expressed_with	gene	0.50

Incoming (2)

Source	Relation	Type	Str
BDNF	activates	gene	0.60
BDNF	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CPLX2 in their description or question text

No additional research found