concept

CELL SURVIVAL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CELL SURVIVAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

144Connections

0Hypotheses

0Analyses

9Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	CELL SURVIVAL
Key Genes/Proteins	AKT, AMPK, AMYLOID, ATF4, BCL2L1, BCL-XL
Related Diseases	aging, APOPTOSIS, BREAST CANCER, cancer

Pathway Diagram

graph TD
    CELL_SURVIVAL["CELL SURVIVAL"]
    CELL_SURVIVAL -->|"regulates"| MITOPHAGY["MITOPHAGY"]
    CELL_SURVIVAL -->|"regulates"| NEURON["NEURON"]
    CELL_SURVIVAL -->|"regulates"| NEURONS["NEURONS"]
    CELL_SURVIVAL -->|"activates"| T_CELL["T CELL"]
    CELL_SURVIVAL -->|"activates"| T_CELLS["T CELLS"]
    CELL_SURVIVAL -->|"activates"| ULK1["ULK1"]
    CELL_SURVIVAL -->|"activates"| MTOR["MTOR"]
    CELL_SURVIVAL -->|"activates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    CELL_SURVIVAL -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
    CELL_SURVIVAL -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    CLOCK["CLOCK"] -->|"regulates"| CELL_SURVIVAL
    PTEN["PTEN"] -->|"inhibits"| CELL_SURVIVAL
    PI3K["PI3K"] -->|"activates"| CELL_SURVIVAL
    PI3K_AKT_mTOR["PI3K-AKT-mTOR"] -->|"activates"| CELL_SURVIVAL
    AMPK["AMPK"] -->|"regulates"| CELL_SURVIVAL
    MTOR -->|"regulates"| CELL_SURVIVAL
    Autophagy["Autophagy"] -->|"involved_in"| CELL_SURVIVAL
    ULK1 -->|"contributes to"| CELL_SURVIVAL

Outgoing (9)

Target	Relation	Type	Str
PROTEIN MISFOLDING	protects_against	phenotype	0.65
PROTEIN MISFOLDING	stabilizes	phenotype	0.60
CORTEX	associated_with	brain_region	0.50
LITHIUM	associated_with	drug	0.50
RESVERATROL	associated_with	concept	0.50
Proteins	expressed_in	protein	0.50
Neuroprotection	activates	process	0.50
GENE EXPRESSION	regulates	concept	0.50
Proteins	activates	protein	0.50

Incoming (135)

Source	Relation	Type	Str
Jak-Stat3	associated_with	pathway	0.95
HER2	regulates	protein	0.95
Mitophagy	promotes	process	0.95
PI3K/AKT/mTOR	regulates	pathway	0.95
ERBB2	regulates	gene	0.95
HER2	promotes	protein	0.95
BCL2	regulates	protein	0.95
Mitochondrial Calcium Transport	regulates	process	0.92
PI3K/AKT/MTOR pathway	promotes	pathway	0.92
CCDC50	associated_with	protein	0.90
MTORC2	mediates	protein	0.90
PTEN	inhibits	gene	0.90
Organelle-Specific Autophagy	involved_in	process	0.90
PI3K-Akt-mTOR Signaling Pathway	regulates	pathway	0.90
CLOCK	regulates	gene	0.90
PI3K/AKT Signaling Pathway	activates	pathway	0.90
PI3K	activates	protein	0.90
OPTN	modulates	protein	0.90
PI3K-AKT-mTOR	activates	pathway	0.90
AMPK	regulates	protein	0.90
MCL1	promotes	gene	0.88
BCL2	promotes	gene	0.88
mitochondrial calcium exchange	regulates	process	0.87
mitochondrial homeostasis	associated_with	process	0.85
IGF2R	regulates	protein	0.85
MAPL	regulates	protein	0.85
PI3K/Akt/mTOR	regulates	pathway	0.85
Hdac Inhibitors	promotes	drug	0.85
IGF2	involved_in	protein	0.85
MCL1	promotes	gene	0.85
stress granule formation	promotes	process	0.85
MAPK	promotes	pathway	0.85
IGF2	regulates	protein	0.85
Nuclear ACSS2	associated_with	protein	0.85
P62	regulates	protein	0.85
BCL2	promotes	gene	0.85
STRESS GRANULE ASSEMBLY	protects_against	entity	0.85
MTOR	regulates	protein	0.80
GAS5	inhibits	gene	0.80
NEAT1	promotes	gene	0.80
autophagy	associated_with	pathway	0.80
HDAC Inhibitors	associated_with	drug	0.80
MALAT1	promotes	gene	0.80
AMPK	contributes_to	protein	0.80
Autophagy	regulates	process	0.80
ULK1	contributes_to	protein	0.80
Autophagy	involved_in	process	0.80
HDAC Inhibitors	upregulates	drug	0.75
MCU	regulates	protein	0.75
Nucleophagy	involved_in	process	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CELL SURVIVAL in their description or question text

No additional research found