concept

CHOROID PLEXUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOROID PLEXUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

1Hypotheses

0Analyses

30Outgoing

24Incoming

2Experiments

0Debates

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💡 Concept Info

Name	CHOROID PLEXUS
Key Genes/Proteins	AMYLOID, APOE, CX3CR1
Related Diseases	AGING, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, AUTISM, CANCER

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Choroid Plexus

cell · 1479 words

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Pathway Diagram

graph TD
    CHOROID_PLEXUS[CHOROID PLEXUS]
    CHOROID_PLEXUS -->|synergizes_with| neuroinflammation[neuroinflammation]
    CHOROID_PLEXUS -->|produces| CEREBROSPINAL_FLUID[CEREBROSPINAL FLUID]
    CHOROID_PLEXUS -->|produces| AGING[AGING]
    CHOROID_PLEXUS -.biomarker for.-> NEUROINFLAMMATION[NEUROINFLAMMATION]
    CHOROID_PLEXUS -->|activates| ALZHEIMER_S_DISEASE[ALZHEIMER'S DISEASE]
    CHOROID_PLEXUS -->|activates| CSF[CSF]
    CHOROID_PLEXUS -->|causes| AMYLOID[AMYLOID]
    NITRIC_OXIDE[NITRIC OXIDE] -->|inhibits| CHOROID_PLEXUS
    CANCER[CANCER] -->|activates| CHOROID_PLEXUS
    ALZHEIMER_S_DISEASE -->|interacts| CHOROID_PLEXUS
    MICROGLIA[MICROGLIA] -->|causes| CHOROID_PLEXUS
    C3[C3] -->|expressed in| CHOROID_PLEXUS
    ferroptosis[ferroptosis] -->|active_in| CHOROID_PLEXUS
    neuroinflammation -->|affects| CHOROID_PLEXUS
    RNA[RNA] -->|expressed in| CHOROID_PLEXUS
    Alzheimer_s_disease[Alzheimer's disease] -->|affects| CHOROID_PLEXUS
    aging[aging] -->|affects| CHOROID_PLEXUS

Outgoing (30)

Target	Relation	Type	Str
neuroinflammation	synergizes_with	process	0.90
ALZHEIMER'S DISEASE	regulates	disease	0.65
CEREBROSPINAL FLUID	produces	phenotype	0.65
AGING	regulates	phenotype	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
AGING	associated_with	phenotype	0.65
NEUROINFLAMMATION	biomarker_for	phenotype	0.65
CSF	activates	phenotype	0.60
CEREBROSPINAL FLUID	activates	phenotype	0.60
AMYLOID	causes	protein	0.60
CEREBROSPINAL FLUID	implicated_in	phenotype	0.55
MACROPHAGES	associated_with	cell_type	0.45
MACROPHAGE	associated_with	cell_type	0.45
AUTISM	associated_with	disease	0.45
APOE	associated_with	gene	0.45
LRP1	associated_with	gene	0.45
T CELLS	associated_with	cell_type	0.45
ASTROCYTES	associated_with	cell_type	0.45
MICROGLIA	associated_with	cell_type	0.45
NEURONS	associated_with	cell_type	0.45
INFLAMMATION	associated_with	phenotype	0.45
FERROPTOSIS	associated_with	phenotype	0.45
DEMENTIA	associated_with	disease	0.45
AMYLOID	associated_with	protein	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
STROKE	associated_with	disease	0.45
MICROGLIAL ACTIVATION	associated_with	phenotype	0.45
CX3CR1	associated_with	gene	0.45
TAU	associated_with	protein	0.45
NITRIC OXIDE	associated_with	phenotype	0.45

Incoming (24)

Source	Relation	Type	Str
IFN	disrupts	gene	0.70
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
MICROGLIA	causes	cell_type	0.65
CANCER	activates	disease	0.65
NITRIC OXIDE	inhibits	phenotype	0.65
C3	expressed_in	gene	0.60
neuroinflammation	affects	disease	0.60
ferroptosis	active_in	pathway	0.60
spinal muscular atrophy	affects	disease	0.60
Alzheimer's disease	affects	disease	0.60
aging	affects	disease	0.60
RNA	expressed_in	gene	0.60
MACROPHAGES	expressed_in	cell_type	0.55
NEURODEGENERATION	associated_with	disease	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
HUNTINGTON'S DISEASE	associated_with	disease	0.45
CEREBRAL AMYLOID ANGIOPATHY	associated_with	disease	0.45
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
MULTIPLE SCLEROSIS	associated_with	disease	0.45
COMPLEMENT ACTIVATION	associated_with	phenotype	0.45
ENDOTHELIAL CELLS	associated_with	cell_type	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Osmotic Gradient Restoration via Selective AQP1 Enhancement	0.680	neurodegeneration	Perivascular spaces and glymphatic clear

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.900	0.50	aortic endothelial cells	proposed	$6,550,000
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs AD with Co	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
AQP1 differentially orchestrates endothelial cell senescence. [PMID:39180980]	Shabanian K, Shabanian T, Karsai G, Pont	Redox Biol	2024	1
Non-Aquaporin Water Channels. [PMID:36717505]	Huang B, Wang H, Yang B	Adv Exp Med Biol	2023	1
Aquaporins in Nervous System. [PMID:28258567]	Xu M, Xiao M, Li S, Yang B	Adv Exp Med Biol	2017	1
Aquaporins in the Spinal Cord. [PMID:27941618]	Oklinski MK, Skowronski MT, Skowronska A	Int J Mol Sci	2016	1
Aquaporin gating. [PMID:16837191]	Hedfalk K, Törnroth-Horsefield S, Nyblom	Curr Opin Struct Biol	2006	1
Panax notoginseng saponins protect the blood-brain barrier against oxidative str [PMID:41763432]	Fan L, Qu S, Miao C, Wu D, Rao Y et al.	Int J Biol Macromol	2026	0
Stomatin encapsulates aquaporin-1 and urea transporter-B in the erythrocyte memb [PMID:41921000]	Vallese F, Li H, Barazzuol L, Calì T, Cl	Sci Adv	2026	0
Aquaporin membrane channels in the hepatobiliary tract: a model of complexity an [PMID:41926019]	Portincasa P, Khalil M, Calamita G	Intern Emerg Med	2026	0
Glycosomal Aquaglyceroporin 1 dual role in iron homeostasis and antimony suscept [PMID:41926379]	Boy RL, Zampieri RA, Aoki JI, Coelho AC,	PLoS Negl Trop Dis	2026	0
Aquaporin-1 Facilitates Macrophage M1 Polarization by Enhancing Glycolysis Throu [PMID:39365391]	["Diao R", "Lv W", "Wang Y", "Shen Q", "	Inflammation	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis. [PMID:34670044]	Morelle J, Marechal C, Yu Z, Debaix H, C	The New England journal of med	2021	0
Discovery of novel diarylamides as orally active diuretics targeting urea transp [PMID:33532188]	["Zhang S", "Zhao Y", "Wang S", "Li M",	Acta pharmaceutica Sinica. B	2021	0
Physiological and pathological impact of AQP1 knockout in mice. [PMID:31023968]	Hua Y, Ying X, Qian Y, Liu H, Lan Y, Xie	Bioscience reports	2019	0
The potential role of aquaporin 1 on aristolochic acid I induced epithelial mese [PMID:29215709]	["Li J", "Zhang M", "Mao Y", "Li Y", "Zh	Journal of cellular physiology	2018	0
Cardiotrophin-1 predicts death or heart failure following acute myocardial infar [PMID:17045183]	["Khan S", "Kelly D", "Quinn P", "Davies	Journal of cardiac failure	2006	0
Regulation of mitosis in response to damaged or incompletely replicated DNA requ [PMID:16079276]	["Purdy A", "Uyetake L", "Cordeiro M", "	Journal of cell science	2005	0
Physiological roles of aquaporins in the choroid plexus. [PMID:15949534]	Boassa D, Yool AJ	Current topics in developmenta	2005	0
Structural basis of ion pumping by Ca2+-ATPase of the sarcoplasmic reticulum. [PMID:15189143]	["Toyoshima C", "Inesi G"]	Annual review of biochemistry	2004	0
Su e of the yeast F1Fo-ATP synthase forms homodimers. [PMID:12377768]	["Brunner S", "Everard-Gigot V", "Stuart	The Journal of biological chem	2002	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHOROID PLEXUS in their description or question text

No additional research found