gene

DDC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections

1Hypotheses

1Analyses

50Outgoing

34Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	DDC
Chromosome	7p12.2
Protein Type	Enzyme
Function	This is critical for PD treatment, as the efficacy of L-DOPA therapy depends on residual AADC activity in surviving nigrostriatal neurons[@lerner2020].
Primary Expression	the substantia nigra pars compacta (SNc), ventral tegmental area (VTA), locus coeruleus, and raphe nuclei—regions critical for movement control, rewar
Molecular Weight	54 kDa
Amino Acids	466 aa
Pathways	NF-kB signaling, circadian regulation, glymphatic clearance, oxidative stress response
Ensembl ID	ENSG00000132437
GeneCards	DDC
Human Protein Atlas	DDC
Associated Diseases	als, alzheimer, Alzheimer's disease, dementia, huntington, ms
Known Drugs/Compounds	levodopa
Interactions	APOE, AQP4, GBA, LRRK2, MT1, SNCA
SciDEX Hypotheses	Correcting Gut Microbial Dopamine Imbalance to Sup
KG Connections	114 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DDC["DDC"]
    Als["Als"]
    Parkinson["Parkinson"]
    AQP4["AQP4"]
    ALZHEIMER["ALZHEIMER"]
    Parkinson_s_disease["Parkinson's disease"]
    neurodegeneration["neurodegeneration"]
    DAT["DAT"]
    SUMF1["SUMF1"]
    GBA["GBA"]
    AADC["AADC"]
    PARKINSON["PARKINSON"]
    LRRK2["LRRK2"]
    GPR109A["GPR109A"]
    CHRNA7["CHRNA7"]
    AGER["AGER"]
    CSGA["CSGA"]
    Genes["Genes"]
    DDC -->|"biomarker_for"| Als
    DDC -->|"biomarker_for"| Parkinson
    AQP4 -.-|"associated"| DDC
    ALZHEIMER -.-|"associated"| DDC
    DDC -->|"biomarker_for"| Parkinson_s_disease
    DDC -->|"studied_in"| neurodegeneration
    DDC -->|"biomarker_for"| DAT
    DDC -->|"biomarker_for"| SUMF1
    DDC -->|"biomarker_for"| GBA
    DDC -->|"biomarker_for"| AADC
    DDC -->|"biomarker_for"| PARKINSON
    DDC -->|"biomarker_for"| LRRK2
    DDC -->|"activates"| GBA
    DDC -->|"activates"| LRRK2
    DDC -.-|"associated"| neurodegeneration
    DDC -.-|"discussed with"| GPR109A
    DDC -.-|"discussed with"| CHRNA7
    DDC -.-|"discussed with"| AGER
    DDC -.-|"discussed with"| CSGA
    Genes -->|"references"| DDC
    style DDC fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (80)

Target	Relation	Type	Str
Dementia with Lewy Bodies	biomarker_for	disease	0.95
dopamine biosynthesis	involved_in	process	0.95
Parkinson's Disease	biomarker_for	disease	0.92
PARKINSON'S DISEASE	treats	disease	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
TH	associated_with	gene	0.70
spinal muscular atrophy	biomarker_for	disease	0.70
neurons	regulates	cell_type	0.70
Als	biomarker_for	disease	0.65
Parkinson	biomarker_for	disease	0.65
TAU	treats	protein	0.65
ALS	biomarker_for	disease	0.65
LRRK2	associated_with	gene	0.60
AND	biomarker_for	gene	0.60
PARKINSON'S DISEASE	biomarker_for	gene	0.60
GBA	associated_with	gene	0.60
L-DOPA	converts	drug	0.60
dementia with Lewy bodies	biomarker_for	disease	0.60
dementia with Lewy bodies	regulates	disease	0.60
dementia with Lewy bodies	colocalizes_in	disease	0.60
substantia nigra	expressed_in	brain_region	0.60
DAT	biomarker_for	gene	0.60
PARKINSON	biomarker_for	gene	0.60
dementia with Lewy bodies	treats	disease	0.60
neurons	protects_against	cell_type	0.60
Parkinson	associated_with	disease	0.60
dementia	associated_with	disease	0.60
Parkinson's disease	treats	disease	0.60
spinal muscular atrophy	treats	disease	0.60
spinal muscular atrophy	regulates	disease	0.60
Alzheimer's disease	regulates	disease	0.60
SUMF1	biomarker_for	gene	0.60
GBA	biomarker_for	gene	0.60
AADC	biomarker_for	gene	0.60
LRRK2	biomarker_for	gene	0.60
Rb	biomarker_for	protein	0.60
Parkinson's disease	biomarker_for	disease	0.60
DOPAMINE	converts	phenotype	0.60
MAO	associated_with	gene	0.60
Parkinson's disease	associated_with	disease	0.60
DRD1	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
App	biomarker_for	protein	0.60
TH	interacts_with	gene	0.60
GBA	activates	gene	0.60
LRRK2	activates	gene	0.60
serotonin	inhibits	neurotransmitter	0.60
serotonin	upstream_of	neurotransmitter	0.60
TH	regulates	gene	0.60

Incoming (34)

Source	Relation	Type	Str
h-d3a64f5c	targets_gene	hypothesis	0.90
SNCA	interacts_with	protein	0.85
TH	interacts_with	gene	0.70
Alzheimer's Disease	associated_with	disease	0.70
AQP4	associated_with	gene	0.65
ALZHEIMER	associated_with	gene	0.65
APOE	interacts_with	gene	0.60
AADC	biomarker_for	gene	0.60
SUMF1	biomarker_for	gene	0.60
GBA	biomarker_for	gene	0.60
LRRK2	biomarker_for	gene	0.60
APOE	associated_with	gene	0.60
levodopa	inhibits	compound	0.60
levodopa	upstream_of	compound	0.60
COMT	associated_with	gene	0.60
GBA MUTATIONS	biomarker_for	gene	0.60
PARKINSON	biomarker_for	gene	0.60
DAT	biomarker_for	gene	0.60
DAT	regulates	gene	0.60
AQP4	co_mentioned	gene	0.55
AQP4	activates	gene	0.55
levodopa	targets	drug	0.55
LEVODOPA	associated_with	drug	0.50
MELATONIN	associated_with	drug	0.50
DEMENTIA	associated_with	disease	0.50
L-DOPA	associated_with	drug	0.50
AGER	debate_co_mention	gene	0.45
CHRNA7	debate_co_mention	gene	0.45
CSGA	debate_co_mention	gene	0.45
PARKINSON	associated_with	disease	0.45
AADC	co_mentioned	gene	0.40
TDC	co_discussed	gene	0.40
HDAC	co_discussed	gene	0.40
TLR4	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.606	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders [PMID:41699128]	["Bolsewig K", "Bellomo G", "Hok-A-Hin Y	Nature medicine	2026
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by [PMID:39881147]	["Bolsewig K", "Willemse E", "S\u00e1nch	Nature communications	2025
Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral ph [PMID:37573958]	["Montillot C", "Skutunova E", "Ayushma"	Neurobiology of disease	2023
Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neu [PMID:36692274]	["Motta C", "Assogna M", "Bonomi C", "Di	European journal of neurology	2023
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425]	Lieberwirth JK, Joset P, Heinze A, Hents	European journal of human gene	2021
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174]	Liu J, Xie J	International journal of envir	2020
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582]	Karas M, Marinsek N, Goldhahn J, Foschin	Digital biomarkers	2020
DOPA Decarboxylase Modulates Tau Toxicity. [PMID:28751068]	["Kow R", "Sikkema C", "Wheeler J", "Wil	Biological psychiatry	2018

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning DDC in their description or question text

No additional research found

DDC