gene

SMN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

0Hypotheses

0Analyses

16Outgoing

6Incoming

0Experiments

0Debates

Summary

Page for SMN2 Gene

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🧬 Gene Info

Gene Symbol	SMN2
Full Name	Survival of Motor Neuron 2, Telomeric
Chromosome	5q13.2.
Function	The SMN complex plays a critical role in pre-mRNA splicing by facilitating the biogenesis of U1, U2, U4, and U5 snRNPs[@pellizzoni2002].
Molecular Weight	32 kDa
Amino Acids	294 aa
UniProt ID	Q16637
NCBI Gene ID	6609
Ensembl ID	ENSG00000120247
OMIM	601627
GeneCards	SMN2
Human Protein Atlas	SMN2
Associated Diseases	Als
Interactions	MOTOR NEURONS, NEURON, Rb, SMN1
KG Connections	22 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMN2 — AlphaFold Q16637 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SMN2 Gene

gene · 1286 words

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SMN2 Protein

protein · 836 words

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Pathway Diagram

graph TD
    SMN2["SMN2"]
    Als{"Als"}
    SMN2 -->|"associated_with"| Als
    ALS{"ALS"}
    SMN2 -->|"associated_with"| ALS
    Spinal_Muscular_Atrophy{"Spinal Muscular Atrophy"}
    SMN2 -->|"interacts_with"| Spinal_Muscular_Atrophy
    MOTOR_NEURONS(["MOTOR NEURONS"])
    SMN2 -->|"therapeutic_target"| MOTOR_NEURONS
    SMN1(["SMN1"])
    SMN2 -->|"expressed_in"| SMN1
    NEURON(["NEURON"])
    SMN2 -->|"therapeutic_target"| NEURON
    AXON(["AXON"])
    AXON -->|"therapeutic_target"| SMN2
    RNA(["RNA"])
    RNA -->|"associated_with"| SMN2
    style SMN2 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (16)

Target	Relation	Type	Str
ALS	associated_with	disease	0.65
Spinal Muscular Atrophy	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Mrna Processing	therapeutic_target	pathway	0.60
MOTOR NEURONS	therapeutic_target	gene	0.60
NEURON	therapeutic_target	gene	0.60
NEURON	interacts_with	gene	0.60
RNA	associated_with	gene	0.60
Neuron	interacts_with	cell_type	0.60
SMN1	expressed_in	gene	0.60
neurons	expressed_in	cell_type	0.60
Rb	interacts_with	protein	0.60
SMN1	interacts_with	gene	0.60
Ras	associated_with	protein	0.60
Spinal Cord	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (6)

Source	Relation	Type	Str
AXON	therapeutic_target	gene	0.60
SMN	associated_with	gene	0.60
SMN1	interacts_with	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
RNA	associated_with	gene	0.60
NEURON	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SMN2 in their description or question text

No additional research found