concept

B CELLS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELLS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

207Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

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💡 Concept Info

Name	B CELLS
Key Genes/Proteins	AKT, AMPK, AQP4, BAX, BCL2, BDNF
Related Diseases	AGING, CANCER

Pathway Diagram

graph TD
    B_CELLS["B CELLS"]
    B_CELLS -->|"mediates"| Tolerance_To_AQP4["Tolerance To AQP4"]
    B_CELLS -->|"activates"| NF_KB["NF-KB"]
    B_CELLS -->|"regulates"| Immune_Tolerance["Immune Tolerance"]
    B_CELLS -->|"contributes to"| Salivary_Gland_Damage["Salivary Gland Damage"]
    B_CELLS -->|"regulates"| AQP4["AQP4"]
    B_CELLS -->|"involved_in"| Neuromyelitis_Optica["Neuromyelitis Optica"]
    DDX5["DDX5"] -->|"regulates"| B_CELLS
    APOPTOSIS["APOPTOSIS"] -->|"activates"| B_CELLS
    AQP4 -->|"activates"| B_CELLS
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| B_CELLS
    AKT["AKT"] -->|"activates"| B_CELLS

Outgoing (93)

Target	Relation	Type	Str
NF-KB	activates	gene	0.95
Tolerance To AQP4	mediates	process	0.95
Tolerance	mediates	process	0.95
AQP4	regulates	protein	0.90
Immune Tolerance	regulates	process	0.90
AQP4	regulates	protein	0.90
Salivary Gland Damage	contributes_to	phenotype	0.90
AQP4	associated_with	protein	0.85
Autoimmune Response	suppresses	process	0.85
Neuromyelitis Optica	involved_in	disease	0.85
AQP4	interacts_with	protein	0.85
Immune Tolerance	mediates	process	0.85
Autoimmune Tolerance	regulates	process	0.85
Neuromyelitis Optica	protects_against	disease	0.85
Immune Tolerance	mediates	process	0.80
MS	associated_with	disease	0.80
neuromyelitis optica spectrum disorder	biomarker_for	disease	0.80
central nervous system	involved_in	brain_region	0.80
Autoimmune Disease	participates_in	disease	0.80
LYMPHOMA	activates	disease	0.80
T CELLS	interacts_with	cell_type	0.80
MACROPHAGES	treats	cell_type	0.70
Neuromyelitis optica spectrum disorder activity	related_to	disease	0.70
T CELLS	activates	cell_type	0.65
LYMPHOMA	interacts_with	disease	0.65
LYMPHOMA	inhibits	disease	0.65
LYMPHOMA	regulates	disease	0.65
INFLAMMATION	activates	process	0.65
MULTIPLE SCLEROSIS	implicated_in	disease	0.55
LYMPHOMA	associated_with	disease	0.55
CASP3	activates	gene	0.50
BCL2	activates	gene	0.50
ENDOTHELIAL CELLS	interacts_with	cell_type	0.50
FIBROBLASTS	interacts_with	cell_type	0.50
MACROPHAGES	activates	cell_type	0.50
IL-6	activates	gene	0.50
DENDRITIC CELLS	associated_with	concept	0.50
BCL2	interacts_with	gene	0.50
BAX	interacts_with	gene	0.50
NEUROTOXICITY	activates	process	0.35
NEURON	activates	cell_type	0.35
TNF	activates	gene	0.35
GAPDH	activates	gene	0.35
CD8	interacts_with	gene	0.35
GLIOBLASTOMA	interacts_with	disease	0.35
IL-10	activates	gene	0.35
VEGF	activates	gene	0.35
CREB	activates	gene	0.35
FIS1	activates	gene	0.35
P53	activates	gene	0.35

Incoming (114)

Source	Relation	Type	Str
29125032	protect	paper	0.90
NF-kB signaling	active_in	pathway	0.90
DDX5	regulates	gene	0.80
spinal muscular atrophy	affects	disease	0.80
CD8	associated_with	gene	0.70
unfolded protein response	active_in	pathway	0.70
CD4	associated_with	gene	0.70
MOG	exacerbates	gene	0.70
AGING	activates	phenotype	0.65
BDNF	activates	gene	0.65
AQP4	treats	gene	0.65
CXCL10	activates	gene	0.65
ROS	activates	phenotype	0.65
AMPK	activates	gene	0.60
IL1B	associated_with	gene	0.60
glutamate signaling	active_in	pathway	0.60
NMDA receptor	expressed_in	receptor	0.60
multiple sclerosis	affects	disease	0.60
RNA	associated_with	gene	0.60
NAMPT	activates	gene	0.60
MYC	activates	gene	0.60
MYC	expressed_in	gene	0.60
GFAP	activates	gene	0.60
GFAP	regulates	gene	0.60
BCL2	regulates	gene	0.60
BCL2	releases	gene	0.60
AMPK signaling	active_in	pathway	0.60
AQP4	inhibits	gene	0.60
AQP4	treats	gene	0.60
Golgi apparatus	found_in	organelle	0.60
ATP	activates	gene	0.60
ATP	regulates	gene	0.60
RNA	expressed_in	gene	0.60
glioblastoma	affects	disease	0.60
TLR	activates	gene	0.60
CD38	regulates	gene	0.60
AQP4	associated_with	gene	0.60
AQP4	activates	gene	0.60
AQP4	expressed_in	gene	0.60
NAD	activates	gene	0.60
DNA	regulates	gene	0.60
DNA	modulates	gene	0.60
MTOR	regulates	gene	0.60
AGING	participates_in	phenotype	0.55
FIBROBLASTS	activates	concept	0.50
CYTOKINES	activates	concept	0.50
Macrophage	activates	cell_type	0.50
CHAT	activates	gene	0.50
NEURONS	activates	concept	0.50
WHITE MATTER	associated_with	brain_region	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.683	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning B CELLS in their description or question text

No additional research found