gene

PSAP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSAP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

171Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

PSAP is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, contributes to. Associated with Als, Atherosclerosis, Cancer. Connected to 62 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PSAP
Aliases	Page for PSAP Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	substantia nigra, Substantia Nigra
Molecular Weight	58.4 kDa
Amino Acids	557 aa
Pathways	Oxidative Phosphorylation, Sphingolipid
GeneCards	PSAP
Human Protein Atlas	PSAP
Associated Diseases	Neurodegeneration, neurodegeneration
Interactions	AND, APOE, AUTOPHAGY, CANCER, CTSD, GALC
KG Connections	171 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PSAP["PSAP"]
    Neurodegeneration{"Neurodegeneration"}
    PSAP -->|"activates"| Neurodegeneration
    Inflammation{"Inflammation"}
    PSAP -->|"activates"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    PSAP -->|"activates"| Neuroinflammation
    Parkinson{"Parkinson"}
    PSAP -->|"activates"| Parkinson
    Ms{"Ms"}
    PSAP -->|"activates"| Ms
    Atherosclerosis{"Atherosclerosis"}
    PSAP -->|"inhibits"| Atherosclerosis
    PSAP -->|"inhibits"| Inflammation
    PSAP -->|"associated with"| Neurodegeneration
    Als{"Als"}
    PSAP -->|"activates"| Als
    PSAP -->|"interacts with"| Ms
    Cancer{"Cancer"}
    PSAP -->|"activates"| Cancer
    Tumor{"Tumor"}
    PSAP -->|"activates"| Tumor
    GPR37["GPR37"]
    GPR37 -->|"activates"| PSAP
    MTOR["MTOR"]
    MTOR -->|"associated with"| PSAP
    APOE["APOE"]
    APOE -->|"therapeutic target"| PSAP
    APOE -->|"regulates"| PSAP
    LDLR["LDLR"]
    LDLR -->|"inhibits"| PSAP
    GALC["GALC"]
    GALC -->|"interacts with"| PSAP
    RAC1["RAC1"]
    RAC1 -->|"activates"| PSAP
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"inhibits"| PSAP
    APOE -->|"inhibits"| PSAP
    AND["AND"]
    AND -->|"activates"| PSAP
    NEURON["NEURON"]
    NEURON -->|"activates"| PSAP
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"activates"| PSAP
    style PSAP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (113)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:PSAP	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
PROSAPOSIN	encodes	protein	0.95
IL-6	associated_with	protein	0.95
GPR37	associated_with	gene	0.92
Atherosclerosis	contributes_to	disease	0.90
Inflammation	mediates	process	0.90
Neurodegeneration	associated_with	process	0.85
Parkinson'S Disease	contributes_to	disease	0.85
Neuroinflammation	promotes	process	0.85
Parkinson'S Disease	involved_in	disease	0.85
Oxidative Phosphorylation	regulates	pathway	0.80
IL6	mediates	protein	0.80
TRAUMATIC BRAIN INJURY	markers	disease	0.70
oxidative stress response	participates_in	pathway	0.70
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	interacts_with	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Neuroinflammation	contributes_to	disease	0.65
Multiple Sclerosis	protects_against	disease	0.65
Als	activates	disease	0.65
Inflammation	contributes_to	disease	0.65
Ms	activates	disease	0.65
Multiple Sclerosis	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Pain	activates	disease	0.65
Parkinson	activates	disease	0.65
IL6	activates	protein	0.64
GPR37	activates	protein	0.64
dopaminergic neurons	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
oligodendrocytes	expressed_in	cell_type	0.60
Parkinson's disease	activates	disease	0.60
AUTOPHAGY	interacts_with	gene	0.60
Raf	inhibits	protein	0.60
APOE	inhibits	gene	0.60
Cytokine	therapeutic_target	protein	0.60
CANCER	activates	gene	0.60
Autophagy	interacts_with	pathway	0.60
CTSD	interacts_with	gene	0.60
SMAD4	activates	gene	0.60
Mtor	encodes	pathway	0.60
LDLR	inhibits	gene	0.60
SMPD1	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60

Incoming (58)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:PSAP	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
MYELIN	therapeutic_target	gene	0.60
MTORC1	therapeutic_target	gene	0.60
GBA	associated_with	gene	0.60
LDLR	associated_with	entity	0.60
AND	activates	gene	0.60
LRP1	interacts_with	gene	0.60
GALC	interacts_with	gene	0.60
RAC1	activates	gene	0.60
GPR37	regulates	entity	0.60
GPR37	associated_with	entity	0.60
MTOR	mediates	entity	0.60
NEURON	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
IL-6	therapeutic_target	gene	0.60
NEUROINFLAMMATION	activates	entity	0.60
MTOR	encodes	gene	0.60
APOE	therapeutic_target	gene	0.60
APOE	regulates	gene	0.60
LDLR	inhibits	gene	0.60
APOE	inhibits	gene	0.60
SMPD1	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
NEUROINFLAMMATION	contributes_to	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
MTORC1	contributes_to	gene	0.60
GPR37	activates	gene	0.60
MTOR	associated_with	gene	0.60
SMPD1	therapeutic_target	gene	0.60
glycolysis	inhibits	pathway	0.60
GALC	contributes_to	gene	0.60
S6K1	inhibits	gene	0.60
AND	inhibits	gene	0.60
ARSA	contributes_to	gene	0.60
GLA	contributes_to	gene	0.60
MYELIN	contributes_to	gene	0.60
IL-6	associated_with	gene	0.60
Neuroinflammation	activates	process	0.50
Neurodegeneration	interacts_with	disease	0.50
SMPD1	protects_against	gene	0.50
GPR37	co_mentioned	gene	0.40
MTOR	co_mentioned	gene	0.40
LDLR	co_mentioned	gene	0.40
LRP1	co_mentioned	gene	0.40
IL-6	interacts_with	gene	0.35
DOPAMINERGIC NEURONS	interacts_with	cell_type	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PSAP in their description or question text

No additional research found