gene 845 words KG: SYN1
Contents

SYN1 Gene

🧬 Gene Info
Gene SymbolSYN1
ChromosomeXp11.23
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionPrimarily neuronal
PathwaysMAPK, mapk
Ensembl IDENSG00000102057
GeneCardsSYN1
Human Protein AtlasSYN1
Genomic Span~50 kb
Exon CountMultiple exons (13+)
Alternative SplicingProduces multiple isoforms (I, II, III)
Associated Diseasesaging, Als, Alzheimer, Alzheimer'S Disease
Known Drugs/Compoundsrapamycin, RAPAMYCIN
InteractionsACTB, Actin, AD, ADAM10, AKT, ALZHEIMER
KG Connections501 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (22)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Quantum Coherence Disruption in Cellular Communication
Score: 0.63
Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62
Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar
Score: 0.61
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
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Related Analyses (13)

Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

See Also (13)

Astrocytes
cell · KG edge: activates
acetylcholine
general · KG edge: co_discussed
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates

Knowledge Graph (12 edges)

ACTB activates SYN1
LAMP1 associated_with SYN1
MTOR associated_with SYN1
LC3 associated_with SYN1
TUBB3 associated_with SYN1
ATG7 activates SYN1
JUN activates SYN1
SQSTM1 associated_with SYN1
MAP2 associated_with SYN1
SYN1 associated_with CTSD

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