gene 2,160 words KG: STAT6
Contents

STAT6 — Signal Transducer and Activator of Transcription 6

🧬 Gene Info
Gene SymbolSTAT6
Full NameSignal Transducer and Activator of Transcription 6
Chromosome12q13.3
Protein TypeTranscription Factor
Functionis a transcription factor activated specifically by interleukin-4 (IL-4) and interleukin-13 (IL-13) receptor signaling.
Amino Acids847 aa
Gene TypeProtein coding
PathwaysAkt, Apoptosis, Blood-Brain Barrier, Differentiation, Dna Repair
UniProt IDP42262
NCBI Gene ID6778
Ensembl IDENSG00000141510
OMIM601512
GeneCardsSTAT6
Human Protein AtlasSTAT6
Associated DiseasesAls, Asthma, Inflammation, Neuroinflammation
Known Drugs/CompoundsBENVITIMOD, curcumin, Curcumin
InteractionsAGING, AHR, AKT, AND, APOPTOSIS, ARNT
KG Connections320 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (10)

Purinergic Signaling Polarization Control
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.67
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91

Related Analyses (4)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

ARG1 — Arginase 1
gene · KG edge: expressed_in
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Astrocytes
entity · KG edge: expressed_in
ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: associated_with
BCL2 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

BENVITIMOD inhibits STAT6
HDAC5 regulates STAT6
STAT6 activates SLC7A11
CLDN1 inhibits STAT6
NRF2 inhibits STAT6
ARNT activates STAT6
AHR activates STAT6
OCLN inhibits STAT6
SLC7A11 activates STAT6
HDAC5 activates STAT6

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)