protein

NPC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

239Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	NPC1
Chromosome	18q11.2
Protein Type	Transporter
Function	It functions as a key transporter in the late endosomal/lysosomal (LE/LY) system[4]
Subcellular Localization	the limiting membrane of late endosomes and lysosomes. It functions as a key transporter in the **late endosomal/lysosom
Pathways	Wnt signaling pathway
GeneCards	NPC1
Human Protein Atlas	NPC1
Associated Diseases	Als, disease, frontotemporal dementia, Ms, neurodegeneration
Interactions	ABCA1, AGING, ALPHA-SYNUCLEIN, AND, APOE3, APOE4
SciDEX Hypotheses	APOE4-driven lysosome-to-ER cholesterol transport
KG Connections	239 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NPC1["NPC1"] -->|"regulates"| Cholesterol["Cholesterol"]
    NPC1["NPC1"] -->|"regulates"| MTOR["MTOR"]
    NPC1["NPC1"] -->|"involved in"| Cholesterol_Transport["Cholesterol Transport"]
    NPC1["NPC1"] -->|"causes"| Niemann_Pick_disease["Niemann_Pick_disease"]
    NPC1["NPC1"] -->|"activates"| Cancer["Cancer"]
    NPC1["NPC1"] -->|"activates"| Aging["Aging"]
    SLC38A9["SLC38A9"] -->|"interacts"| NPC1["NPC1"]
    CGAS["CGAS"] -->|"interacts"| NPC1["NPC1"]
    STING["STING"] -->|"interacts"| NPC1["NPC1"]
    SREBP2["SREBP2"] -->|"associated"| NPC1["NPC1"]
    style NPC1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (159)

Target	Relation	Type	Str
cholesterol accumulation	promotes	phenotype	0.95
Niemann-Pick disease type C1	causes	disease	0.95
Cholesterol Accumulation	regulates	process	0.95
Niemann-Pick Type C1 Disease	associated_with	disease	0.95
MTOR	activates	protein	0.92
Cholesterol Transport	mediates	process	0.90
SLC38A9	binds	protein	0.90
cell proliferation	inhibits	process	0.90
cell apoptosis	promotes	process	0.90
E-cadherin	modulates	protein	0.90
Wnt signaling pathway	regulates	pathway	0.90
cholesterol transport	regulates	process	0.90
MTOR	inhibits	protein	0.88
lysosomal cholesterol export	regulates	process	0.87
SREBP2	interacts_with	protein	0.85
MYC	upstream_of	gene	0.85
Cholesterol Transport	involved_in	process	0.85
MTOR	regulates	protein	0.85
Alpha-Synuclein-Induced Retinal Degeneration	modulates	phenotype	0.85
Neurodegeneration	contributes_to	disease	0.80
Niemann_Pick_disease	causes	disease	0.72
cholesterol accumulation	causes	process	0.70
TFEB	activates	gene	0.70
late endosome/lysosome	regulates	cell_type	0.70
Lewy Body	activates	disease	0.65
ALS	activates	disease	0.65
Parkinson	inhibits	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Retinal Degeneration	activates	disease	0.65
ALS	inhibits	disease	0.65
Autoimmune	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
Infection	interacts_with	disease	0.65
Als	regulates	disease	0.65
Als	activates	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	regulates	disease	0.65
Als	inhibits	disease	0.65
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Autoimmune	interacts_with	disease	0.65
STING1	interacts_with	gene	0.64
STING1	regulates	gene	0.64

Incoming (80)

Source	Relation	Type	Str
SLC38A9	interacts_with	protein	0.90
ABCA1	inhibits	gene	0.60
GBA1	inhibits	gene	0.60
GBA1	associated_with	gene	0.60
HMGCR	expressed_in	gene	0.60
CNBP	associated_with	gene	0.60
DMPK	associated_with	gene	0.60
MTOR	activates	gene	0.60
LDLR	interacts_with	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
DSDNA	inhibits	gene	0.60
AND	expressed_in	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
LYSOSOME	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	causes	gene	0.60
AND	regulates	gene	0.60
AND	causes	gene	0.60
APOE3	activates	gene	0.60
ATP	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
JAK2	protects_against	gene	0.60
GBA	activates	gene	0.60
LRRK2	inhibits	gene	0.60
RAB8A	inhibits	gene	0.60
CYP46A1	expressed_in	gene	0.60
CTSD	activates	gene	0.60
MTOR	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
RAB8A	regulates	gene	0.60
LRRK2	regulates	gene	0.60
APOE4	activates	gene	0.60
SREBP2	associated_with	gene	0.60
DNA	interacts_with	gene	0.60
EXOSOMES	interacts_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
EXOSOMES	causes	gene	0.60
CANCER	activates	gene	0.60
MTORC1	interacts_with	gene	0.60
SREBP2	transports	gene	0.60
EXOSOMES	transports	gene	0.60
STING	interacts_with	gene	0.60
CGAS	activates	gene	0.60
SCARB2	associated_with	gene	0.60
UBE2D1	associated_with	gene	0.60
LGALS1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-driven lysosome-to-ER cholesterol transport failure re	0.690	molecular biology	Does APOE4's reduced lipid-binding direc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPC1 in their description or question text

No additional research found