gene 640 words KG: SFN
Contents

SFN Gene

🧬 Gene Info
Gene SymbolSFN
Full NameStratifin (14-3-3 sigma)
Chromosome1p36.22
FunctionSFN encodes 14-3-3 sigma, which has unique functions in neurons
Primary Expressionvarious tissues with notable brain expression in: - Cerebral cortex - Hippocampus - [Cerebellum
PathwaysAutophagy, Cell Cycle, Differentiation, Epigenetic, Nf-Κb
UniProt IDP31947
NCBI Gene ID6278
Ensembl IDENSG00000175793
OMIM605225
GeneCardsSFN
Human Protein AtlasSFN
Associated DiseasesCancer, Lung Cancer, neurodegeneration, Tumor
Known Drugs/Compoundsdasatinib, NFE2L2, quercetin, rapamycin
InteractionsAGING, AMPK, APOPTOSIS, ATG5, AUTOPHAGY, BAX
KG Connections108 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Neurodegeneration
disease · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: associated_with
Apoptosis in Neurodegeneration
entity · KG edge: activates
IL6 (Redirect)
redirect · KG edge: regulates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: associated_with

Knowledge Graph (12 edges)

ATG5 activates SFN
ULK1 associated_with SFN
MTOR associated_with SFN
SFN activates LC3
SFN activates NFE2L2
NFE2L2 regulates SFN
NRF2 regulates SFN
KEAP1 regulates SFN
SFN regulates NRF2
SLC7A11 activates SFN

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