gene

WIF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WIF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

WIF1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, activates, implicated in. Associated with Alzheimer, Alzheimer's Disease, Cancer. Connected to 45 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WIF1
Aliases	Page for WIF1 Gene, Page for WIF1 Protein
Chromosome	12q14.3
Function	WIF1 is a key regulator of the Wnt/β-catenin signaling pathway
Primary Expression	Brain, Eye, Lung, Testis, Cartilage
Molecular Weight	36.5 kDa
Pathways	Wnt, Wnt signaling, Wnt Signaling, Wnt pathway
UniProt ID	Q9Y5W5
NCBI Gene ID	11197
Ensembl ID	ENSG00000156076
OMIM	605326
GeneCards	WIF1
Human Protein Atlas	WIF1
Associated Diseases	Cancer, Lung Cancer, neurodegeneration, Tumor, Visual Function
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID, AND, AUTOPHAGY
KG Connections	114 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: WIF1 — AlphaFold Q9Y5W5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

WIF1 Gene - Wnt Inhibitory Factor

gene · 566 words

→

WIF1 Protein - Wnt Inhibitory Factor

protein · 568 words

→

Pathway Diagram

graph TD
    WIF1["WIF1"]
    Alzheimer{"Alzheimer"}
    WIF1 -->|"therapeutic target"| Alzheimer
    Schizophrenia{"Schizophrenia"}
    WIF1 -->|"therapeutic target"| Schizophrenia
    WIF1 -->|"inhibits"| Alzheimer
    NPTX2["NPTX2"]
    WIF1 -->|"inhibits"| NPTX2
    MET["MET"]
    WIF1 -->|"associated with"| MET
    Wnt(["Wnt"])
    WIF1 -->|"associated with"| Wnt
    AMPK["AMPK"]
    WIF1 -->|"therapeutic target"| AMPK
    Amyloid(["Amyloid"])
    WIF1 -->|"therapeutic target"| Amyloid
    Tau_Phosphorylation(["Tau Phosphorylation"])
    WIF1 -->|"therapeutic target"| Tau_Phosphorylation
    DISC1["DISC1"]
    WIF1 -->|"therapeutic target"| DISC1
    WIF1 -->|"activates"| Wnt
    TAU["TAU"]
    WIF1 -->|"inhibits"| TAU
    GENES["GENES"]
    GENES -->|"inhibits"| WIF1
    NPTX2 -->|"inhibits"| WIF1
    AMPK -->|"therapeutic target"| WIF1
    AMYLOID["AMYLOID"]
    AMYLOID -->|"inhibits"| WIF1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"inhibits"| WIF1
    MET -->|"associated with"| WIF1
    AMPK -->|"inhibits"| WIF1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"inhibits"| WIF1
    AND["AND"]
    AND -->|"associated with"| WIF1
    TAU -->|"inhibits"| WIF1
    style WIF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (79)

Target	Relation	Type	Str
Wnt Signaling Antagonism	mediates	mechanism	0.95
Wnt Signaling Pathway	inhibits	pathway	0.95
Photoreceptor Cells	protects_against	cell_type	0.95
Photoreceptor Cell Damage	protects_against	phenotype	0.90
Wnt Signaling	inhibits	pathway	0.90
Visual Function	associated_with	phenotype	0.90
Mitochondrial Damage	protects_against	phenotype	0.90
Diabetic Retinopathy	treats	disease	0.85
Wnt Signaling	regulates	pathway	0.85
GLUT1	downregulates	protein	0.85
Diabetic Retinopathy	protects_against	disease	0.85
Alzheimer's Disease	downregulates	disease	0.85
Photoreceptor Mitochondria	associated_with	organelle	0.80
GSK3B	regulates	protein	0.80
photoreceptor function	protects_against	process	0.70
Wnt signaling	participates_in	pathway	0.70
Alzheimer	therapeutic_target	disease	0.65
Retinopathy	inhibits	disease	0.65
Lung Cancer	implicated_in	disease	0.65
Tumor	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Schizophrenia	therapeutic_target	disease	0.65
TAU	therapeutic_target	gene	0.60
Wnt	activates	pathway	0.60
NPTX2	inhibits	gene	0.60
MET	associated_with	gene	0.60
TAU	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
RNA	inhibits	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
HIF-1Α	inhibits	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GMPR	therapeutic_target	gene	0.60
App	therapeutic_target	protein	0.60
DISC1	therapeutic_target	gene	0.60
neurodegeneration	inhibits	disease	0.60
ALZHEIMER	inhibits	gene	0.60
neurodegeneration	associated_with	disease	0.60
WNT	associated_with	gene	0.60
GMPR	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
GSK3	associated_with	gene	0.60
AND	associated_with	gene	0.60
App	associated_with	protein	0.60
Wnt	associated_with	pathway	0.60
Invasion	activates	pathway	0.60
Autophagy	activates	pathway	0.60

Incoming (35)

Source	Relation	Type	Str
Diabetic Retinopathy	downregulates	disease	0.90
AMYLOID	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
GSK3	regulates	gene	0.60
TAU	therapeutic_target	gene	0.60
RNA	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
DIABETIC RETINOPATHY	inhibits	gene	0.60
HIF-1Α	inhibits	gene	0.60
GLUT1	inhibits	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
WNT	inhibits	gene	0.60
HIF	inhibits	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
AND	inhibits	gene	0.60
MET	associated_with	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
TLR4	activates	gene	0.60
MYO7A	implicated_in	gene	0.60
MET	inhibits	gene	0.60
MET	regulates	gene	0.60
AXIN2	activates	gene	0.60
GSK3	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
WNT	associated_with	gene	0.60
RNA	associated_with	gene	0.60
NPTX2	inhibits	gene	0.60
GENES	inhibits	gene	0.60
AMPK	therapeutic_target	gene	0.60
AUTOPHAGY	activates	gene	0.60
TAU	inhibits	gene	0.60
NPTX2	regulates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WIF1 in their description or question text

No additional research found