| Gene Symbol | SCN5A |
| Chromosome | 3p21 |
| Protein Type | Gene |
| Function | encodes a large transmembrane protein of 2016 amino acids forming the alpha subunit of the cardiac sodium channel. |
| Amino Acids | 2016 aa |
| Exons | 28 |
| GeneCards | SCN5A |
| Human Protein Atlas | SCN5A |
| Four homologous domains (I-IV) | Each containing six transmembrane segments (S1-S6) |
| Voltage sensor domain (VSD) | Segments S1-S4 respond to membrane depolarization |
| Pore domain | Segments S5-S6 form the ion selectivity filter |
| N-terminal domain | Contains inactivation gate and interaction sites |
| C-terminal domain | Modulates channel gating and protein interactions |
| Canonical isoform | Full-length Nav1.5 (2016 aa) |
| Alternative splicing | Produces functionally distinct isoforms |
| Associated Diseases | Aging, Als, Alzheimer, Autism, Cancer, Carcinoma |
| KG Connections | 157 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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