gene

GFRA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GFRA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

25Connections

0Hypotheses

0Analyses

14Outgoing

11Incoming

0Experiments

0Debates

Summary

Page for GFRA1 Gene

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🧬 Gene Info

Gene Symbol	GFRA1
Chromosome	10q25.3
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	51 kDa
Amino Acids	464 aa
Exons	20
Pathways	PI3K, MAPK
GeneCards	GFRA1
Human Protein Atlas	GFRA1
Associated Diseases	neurodegeneration
Interactions	AKT, ERK1, GDNF, PI3K, RET
KG Connections	25 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GFRA1 Gene

gene · 1151 words

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Pathway Diagram

graph TD
    GFRA1["GFRA1"]
    Ms{"Ms"}
    GFRA1 -->|"regulates"| Ms
    Apoptosis(["Apoptosis"])
    GFRA1 -->|"regulates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    GFRA1 -->|"implicated in"| neurodegeneration
    TP53["TP53"]
    TP53 -->|"regulates"| GFRA1
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"regulates"| GFRA1
    FGFR2["FGFR2"]
    FGFR2 -->|"regulates"| GFRA1
    style GFRA1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
Ms	regulates	disease	0.65
neurodegeneration	regulates	disease	0.60
PI3K	protects_against	gene	0.60
RET	protects_against	gene	0.60
PI3K	interacts_with	gene	0.60
RET	interacts_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
RET	regulates	gene	0.60
Apoptosis	regulates	pathway	0.60
Stem Cell	regulates	pathway	0.60
Chemoresistance	regulates	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
GDNF	interacts_with	gene	0.70
AKT	protects_against	gene	0.60
ERK1	protects_against	gene	0.60
GDNF	protects_against	gene	0.60
AKT	interacts_with	gene	0.60
ERK1	interacts_with	gene	0.60
GENES	regulates	gene	0.60
TP53	regulates	gene	0.60
GDNF	regulates	gene	0.60
FGFR2	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GFRA1 in their description or question text

No additional research found