gene

RET

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

132Connections
29Hypotheses
0Analyses
50Outgoing
44Incoming
8Experiments
0Debates

Summary

RET is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Cancer, Carcinoma. Connected to 49 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRET
Chromosome10q11.21
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight120 kDa
Amino Acids114 aa
Exons21
PathwaysPI3K, mTOR, mtor, MAPK
GeneCardsRET
Human Protein AtlasRET
Associated DiseasesAls, Ataxia, Melanoma, Ms, Parkinson
InteractionsAKT, AND, APOPTOSIS, CANCER, CDKN2A, DNA
KG Connections132 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

RET Gene

gene · 1125 words

RETREG3 (Reticulophagy Regulator 3)

gene · 2881 words

RET Protein

protein · 998 words

Pathway Diagram

graph TD
    RET["RET"]
    Als{"Als"}
    RET -->|"inhibits"| Als
    Neuropathy{"Neuropathy"}
    RET -->|"inhibits"| Neuropathy
    Ms{"Ms"}
    RET -->|"activates"| Ms
    Cancer{"Cancer"}
    RET -->|"activates"| Cancer
    Tumor{"Tumor"}
    RET -->|"inhibits"| Tumor
    ERBB2["ERBB2"]
    RET -->|"inhibits"| ERBB2
    GENES["GENES"]
    RET -->|"associated with"| GENES
    ERBB3["ERBB3"]
    RET -->|"inhibits"| ERBB3
    NRG1["NRG1"]
    RET -->|"inhibits"| NRG1
    CANCER["CANCER"]
    RET -->|"activates"| CANCER
    EGFR["EGFR"]
    RET -->|"activates"| EGFR
    AND["AND"]
    RET -->|"inhibits"| AND
    style RET fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (88)

TargetRelationTypeStr
neuronsexpressed_incell_type0.80
apoptosis pathwayparticipates_inpathway0.70
GENESassociated_withgene0.70
neurodegenerationregulatesdisease0.70
oxidative stress responseparticipates_inpathway0.70

Incoming (44)

SourceRelationTypeStr
genes-retdescribeswiki1.00
genes-retdocumentswiki1.00
GDNFactivatesgene0.80
GDNFregulatesgene0.70
NCOA4interacts_withgene0.60

Targeting Hypotheses (29)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Hypothesis 7: SST-SST1R/Gamma Entrainment-Enhanced Astrocyte 0.839 neurodegeneration View
VPS35 retromer activation prevents endosomal tau templating 0.740 neurodegeneration Which tau propagation mechanism predomin
Metabolic-Support Secretome Dysfunction 0.730 neurodegeneration Which specific factors in conditioned me
SASP Secretome-based Molecular Distinction via CXCL1/CXCL2/M 0.720 neurodegeneration How can senescent microglia be molecular
Retinal Vascular Microcirculation Rescue 0.718 neurodegeneration Digital biomarkers and AI-driven early d
APOE4-driven lysosome-to-ER cholesterol transport failure re 0.707 molecular biology Does APOE4's reduced lipid-binding direc
Pericyte-targeted senolysis or senomorphic therapy will bene 0.700 neurodegeneration Does pericyte senescence drive BBB break
Rab27A/B-mediated exosomal tau secretion from microglia driv 0.690 neurodegeneration Which tau propagation mechanism predomin
Hypocretin-Neurogenesis Coupling Therapy 0.688 neurodegeneration Sleep disruption as cause and consequenc
SASP-Secreted MMP-9 from Senescent Microglia Generates Patho 0.686 ALS What are the mechanisms by which microgl
Axonal Transport Defect: C9orf72 hexanucleotide expansion im 0.660 neurodegeneration What are the neuron-specific effects of
Clusterin (APOJ) Secretion Deficit 0.660 neurodegeneration Which specific factors in conditioned me
Retromer-dependent retrograde endosomal signaling compartmen 0.620 neuroscience How can subcellular compartmentalization
Astrocyte LRP1-mediated tau uptake and APOE4-dependent secre 0.610 neurodegeneration Which tau propagation mechanism predomin
GFAP Perivascular Redistribution (End-Feet Retraction) as Tr 0.594 - Blood-brain barrier permeability changes
TBK1 Phosphorylation State Creates Phospho-Regulated Periphe 0.577 neurodegeneration What determines the spatial organization
P2RX7-Mediated Exosome Secretion Blockade 0.552 neurodegeneration Tau propagation mechanisms and therapeut
P2Y6R activation by UDP from damaged neurons drives microgli 0.540 neurodegeneration Which tau propagation mechanism predomin
Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigeneti 0.540 neurodegeneration epigenetic reprogramming aging neurons
GDNF-RET Trophic Signaling Deficit 0.530 neurodegeneration Which specific factors in conditioned me
VPS35 Retromer Restoration to Rescue Endosomal Protein Traff 0.517 proteomics Quantitative proteomics of the aging syn
TYROBP Network Hyperactivation Marks Point of No Return 0.463 neurodegeneration What is the optimal therapeutic window f
HSP70/HSP40 Chaperone Complex Secretion 0.380 neurodegeneration Which specific factors in conditioned me
P2RY12 activation induces cellular senescence in cerebral VS 0.373 neurodegeneration How does P2RY12-mediated VSMC dysfunctio
Reticulocalbin-2 bridges calcineurin to lysosomal membranes 0.360 neurodegeneration What determines the specificity of calci
SASP-Secreted MMP-9 from Senescent Microglia Disrupts Nuclea 0.000 ALS What are the mechanisms by which microgl
TFEB-Mediated Retromer Biogenesis to Restore Endosomal-Lysos 0.000 proteomics Quantitative proteomics of the aging syn
Astrocytic Complement Regulator Secretion Modulates Synaptic 0.000 synaptic biology What determines the selectivity of compl
VPS26A Subunit Enhancement to Stabilize Retromer Complex Ass 0.000 proteomics Quantitative proteomics of the aging syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Proposed experiment from debate on Perivascular spaces and glymphatic falsification Neurodegeneration 0.400 0.50 cell_line proposed $100,000
Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur validation Neurodegeneration 0.400 0.50 cell_line proposed $130,000
Prodromal Parkinson's Disease Biomarker Development — Early Detection clinical Parkinson's Disease 0.400 0.50 human proposed $6,550,000
Vascular Contribution to Alzheimer's Disease — Beyond Amyloid validation Alzheimer's Disease 0.400 0.50 human proposed $2,280,000
Vascular Contributions to Alzheimer Disease and Mixed Pathology clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000
Brainstem Circuit Modulation for PSP clinical ALS 0.400 0.50 human proposed $5,460,000
Neural Stem Cell Therapy for Alzheimer's Disease clinical Alzheimer's Disease 0.400 0.50 human proposed $5,460,000
Sleep and Respiratory Network Interaction in ALS — Experiment Design clinical ALS 0.400 0.50 human proposed $5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Pericyte-derived extracellular vesicles improve vascular barrier function in sep [PMID:39940043] Zhang ZS, Yang A, Luo X, Zhou HN, Liu YY Stem Cell Res Ther 2025 1
Irisin promotes fracture healing by improving osteogenesis and angiogenesis. [PMID:36196152] Kan T, He Z, Du J, Xu M, Cui J, Han X, T J Orthop Translat 2022 1
STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blocka [PMID:31343989] Yang H, Lee WS, Kong SJ, Kim CG, Kim JH, J Clin Invest 2019 1
EMI1 switches from being a substrate to an inhibitor of APC/C(CDH1) to start the [PMID:29875408] Cappell SD, Mark KG, Garbett D, Pack LR, Nature 2018 1
Metabolic fate of glucose and candidate signaling and excess-fuel detoxification [PMID:28280244] Mugabo Y, Zhao S, Lamontagne J, Al-Mass J Biol Chem 2017 1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970] Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th Science 2013 1
Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitoch [PMID:19879861] Xu S, Zhou Z, Zhang L, Yu Z, Zhang W, Wa Brain Res 2010 1
Nucleotide signaling and cutaneous mechanisms of pain transduction. [PMID:19171165] Dussor G, Koerber HR, Oaklander AL, Rice Brain Res Rev 2009 1
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405] Li S, Yan Z, Zhi X, Zheng W, Zhang Z et Bioact Mater 2026 0
Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939] Wan D, Qi Y, Kang Y, Liang F, Wang Q et RSC Med Chem 2026 0
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906] Gao Z, Wang Y, Ren Y, Lyu J J Neurochem 2026 0
VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560] Lee S, Park S, Bang H, Kim SU, Park YH e Genes (Basel) 2026 0
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663] Song P, Chen C, Franchini R, Duong B, Wa J Clin Invest 2026 0
The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708] Buneeva OA, Medvedev AE Biomed Khim 2026 0
Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978] Deng IB, Bu M, Follett J, Sharp R, Mamai bioRxiv 2026 0
Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440] Santinelli L, Pratuseviciute N, Lange LM Mov Disord 2026 0
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn Pathology international 2026 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-c [PMID:37941480] ["De Coninck S", "De Smedt R", "Linterma Haematologica 2024 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RET in their description or question text

APOE4-driven lysosome-to-ER cholesterol transport failure reduces ER-accessible

Score: 0.707 · molecular biology · 2026-04-24

The strongest synthesis is an indirect mechanism in glia: APOE4 promotes cholesterol sequestration in late endosome/lyso

Pericyte-targeted senolysis or senomorphic therapy will benefit only an early bi

Score: 0.700 · neurodegeneration · 2026-04-25

Therapeutic benefit from pericyte-directed senescence interventions depends on stage. If BBB leak and dysfunction occur

Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex pr

Score: 0.690 · neurodegeneration · 2026-04-21

## Mechanistic Overview Rab27A/B-mediated exosomal tau secretion from microglia drives frontal cortex propagation at Bra

Hypocretin-Neurogenesis Coupling Therapy

Score: 0.688 · neurodegeneration · 2026-04-02

## Mechanistic Overview Hypocretin-Neurogenesis Coupling Therapy starts from the claim that modulating HCRT within the d

SASP-Secreted MMP-9 from Senescent Microglia Generates Pathological TDP-43 C-Ter

Score: 0.686 · ALS · 2026-04-26

The hypothesis proposes that MMP-9 (matrix metalloproteinase-9), secreted via the senescence-associated secretory phenot

Axonal Transport Defect: C9orf72 hexanucleotide expansion impairs retrograde aut

Score: 0.660 · neurodegeneration · 2026-04-21

## Mechanistic Overview Axonal Transport Defect: C9orf72 hexanucleotide expansion impairs retrograde autophagosome trans

Clusterin (APOJ) Secretion Deficit

Score: 0.660 · neurodegeneration · 2026-04-25

Healthy astrocytes secrete clusterin, a chaperone glycoprotein that prevents stress-induced protein aggregation and stab

Retromer-dependent retrograde endosomal signaling compartmentalization as biomar

Score: 0.620 · neuroscience · 2026-04-26

VPS26/VPS29/VPS35 retromer complex maintains axonal endosomal signaling microdomains controlling TrkB/p75NTR trafficking

Astrocyte LRP1-mediated tau uptake and APOE4-dependent secretion creates regiona

Score: 0.610 · neurodegeneration · 2026-04-21

## Mechanistic Overview Astrocyte LRP1-mediated tau uptake and APOE4-dependent secretion creates regional susceptibility

GFAP Perivascular Redistribution (End-Feet Retraction) as True BBB Dysfunction B

Score: 0.594 · unknown disease · 2026-04-26

Spatial redistribution of GFAP from astrocyte end-feet to soma — not upregulation — is the mechanistically relevant BBB-

TBK1 Phosphorylation State Creates Phospho-Regulated Peripheral Retention Thresh

Score: 0.577 · neurodegeneration · 2026-04-21

## Mechanistic Overview TBK1 Phosphorylation State Creates Phospho-Regulated Peripheral Retention Threshold starts from

P2RX7-Mediated Exosome Secretion Blockade

Score: 0.552 · neurodegeneration · 2026-04-12

## Mechanistic Overview P2RX7-Mediated Exosome Secretion Blockade starts from the claim that modulating P2RX7 within the

P2Y6R activation by UDP from damaged neurons drives microglial phagocytosis and

Score: 0.540 · neurodegeneration · 2026-04-21

## Mechanistic Overview P2Y6R activation by UDP from damaged neurons drives microglial phagocytosis and exosomal re-secr

Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigenetic Age and Restores V

Score: 0.540 · neurodegeneration · 2026-04-22

## Mechanistic Overview Transient OCT4/SOX2/KLF4/c-MYC Expression Reverses Epigenetic Age and Restores Visual Function i

GDNF-RET Trophic Signaling Deficit

Score: 0.530 · neurodegeneration · 2026-04-25

Healthy astrocytes secrete GDNF, which activates RET receptor signaling on motor neurons, promoting microtubule-dependen