gene

CD55

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD55: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

1Hypotheses

0Analyses

22Outgoing

8Incoming

0Experiments

0Debates

Summary

Page for CD55

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🧬 Gene Info

Gene Symbol	CD55
Chromosome	1q32.2.
Protein Type	Gene
Function	is a cell surface protein encoded by the CD55 gene located on chromosome 1q32.
Primary Expression	human tissues: - Hematopoietic cells (T cells, B cells, monocytes) - Endothelial cells - Epithelial cells - Neurons and glia in the brain - Peripheral
Amino Acids	381 aa
Exons	11
Pathways	JAK-STAT signaling, NF-kB signaling, complement cascade, unfolded protein response
GeneCards	CD55
Human Protein Atlas	CD55
Associated Diseases	neurodegeneration
Interactions	C1QA, C3, C4B, CD46, CD59, CFH
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CD55

gene · 732 words

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Pathway Diagram

flowchart TD
    N0["CD55"]
    N1["C4B"]
    N1 -->|"regulated by"| N0
    N2["CD46"]
    N2 -->|"activates"| N0
    N3["CD33"]
    N3 -->|"regulates"| N0
    N4["neurons"]
    N0 -->|"expressed in"| N4
    N5["EPHA1"]
    N0 -->|"regulates"| N5
    N6["PILRA"]
    N0 -->|"regulates"| N6
    N7["PILRB"]
    N0 -->|"regulates"| N7
    N8["RET"]
    N0 -->|"regulates"| N8
    N9["TREM2"]
    N0 -->|"regulates"| N9
    N10["Alzheimer's disease"]
    N0 -->|"regulates"| N10
    N11["CD59"]
    N0 -->|"activates"| N11

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 cell_type
    class N5 gene
    class N6 gene
    class N7 gene
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    class N9 gene
    class N10 disease
    class N11 gene

Outgoing (22)

Target	Relation	Type	Str
neurons	expressed_in	cell_type	0.75
Alzheimer's disease	regulates	disease	0.60
EPHA1	regulates	gene	0.60
PILRA	regulates	gene	0.60
PILRB	regulates	gene	0.60
RET	regulates	gene	0.60
TREM2	regulates	gene	0.60
CFH	activates	gene	0.55
LIMK1	activates	gene	0.55
ROCK1	activates	gene	0.55
JAK-STAT signaling	participates_in	pathway	0.55
NF-kB signaling	participates_in	pathway	0.55
unfolded protein response	participates_in	pathway	0.55
astrocytes	expressed_in	cell_type	0.55
CD59	activates	gene	0.55
RNA	activates	gene	0.55
STAT3	activates	gene	0.55
CD59	regulates	gene	0.55
complement cascade	participates_in	pathway	0.55
CD59	inhibits	gene	0.55
IDE	activates	gene	0.55
JAK2	activates	gene	0.55

Incoming (8)

Source	Relation	Type	Str
C4B	regulated_by	gene	0.80
CD46	regulates	gene	0.65
CD46	activates	gene	0.65
CD33	regulates	gene	0.60
C1QA	activates	gene	0.55
C3	inhibits	gene	0.55
CD46	inhibits	gene	0.55
C4B	activates	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Differential Complement Regulator Expression on Synaptic Mem	0.725	synaptic biology	What determines the selectivity of compl

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD55 in their description or question text

No additional research found