gene

TRKC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRKC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

39Outgoing

32Incoming

0Experiments

0Debates

Summary

Page for TRKC Gene

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🧬 Gene Info

Gene Symbol	TRKC
Chromosome	15q25.3
Protein Type	Receptor
Function	TrkC is the primary receptor for neurotrophin-3 (NT-3)
Primary Expression	proprioceptive neurons, motor neurons, and certain populations of hippocampal and cortical neurons
Subcellular Localization	</strong></td><td>Plasma membrane, endosomes</td></tr>
Molecular Weight	145 kDa
Amino Acids	821 aa
Exons	26
Pathways	signaling: - Supports sensory neuron survival, PI3K, MAPK
GeneCards	TRKC
Human Protein Atlas	TRKC
Leucine-rich repeats (LRRs)	Mediate initial ligand binding specificity
Cysteine-rich domains	Stabilize ligand-receptor interactions
Ig-like C2-type domains	Provide additional ligand interaction surfaces
Associated Diseases	Alzheimer
Interactions	ALZHEIMER, AMYLOID, Amyloid Beta, AND, Aβ, Bdnf
KG Connections	71 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

TrkC Protein

protein · 974 words

→

TRKC Gene

gene · 757 words

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Pathway Diagram

graph TD
    TRKC["TRKC"]
    Alzheimer["Alzheimer"]
    TRKC -->|"activates"| Alzheimer
    Alzheimer["Alzheimer"]
    TRKC -->|"associated with"| Alzheimer
    TRKB["TRKB"]
    TRKC -->|"regulates"| TRKB
    Synaptic_Plasticity["Synaptic Plasticity"]
    TRKC -->|"activates"| Synaptic_Plasticity
    Microglia["Microglia"]
    TRKC -->|"activates"| Microglia
    Neuron["Neuron"]
    TRKC -->|"activates"| Neuron
    TRKB["TRKB"]
    TRKC -->|"interacts with"| TRKB
    Apoptosis["Apoptosis"]
    TRKC -->|"associated with"| Apoptosis
    Neuron["Neuron"]
    TRKC -->|"associated with"| Neuron
    Amyloid["Amyloid"]
    TRKC -->|"activates"| Amyloid
    Long_Term_Potentiation["Long-Term Potentiation"]
    TRKC -->|"regulates"| Long_Term_Potentiation
    Long_Term_Potentiation["Long-Term Potentiation"]
    TRKC -->|"associated with"| Long_Term_Potentiation
    AMYLOID["AMYLOID"]
    AMYLOID -->|"activates"| TRKC
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| TRKC
    APP["APP"]
    APP -->|"regulates"| TRKC
    NEURON["NEURON"]
    NEURON -->|"activates"| TRKC
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| TRKC
    TRKA["TRKA"]
    TRKA -->|"interacts with"| TRKC
    MAO["MAO"]
    MAO -->|"associated with"| TRKC
    NGF["NGF"]
    NGF -->|"interacts with"| TRKC
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"associated with"| TRKC
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| TRKC
    NTRK2["NTRK2"]
    NTRK2 -->|"associated with"| TRKC
    BDNF["BDNF"]
    BDNF -->|"interacts with"| TRKC
    TRKB["TRKB"]
    TRKB -->|"regulates"| TRKC
    AND["AND"]
    AND -->|"regulates"| TRKC
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| TRKC
    TRKB["TRKB"]
    TRKB -->|"interacts with"| TRKC
    AND["AND"]
    AND -->|"interacts with"| TRKC
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated with"| TRKC

Outgoing (39)

Target	Relation	Type	Str
Alzheimer	associated_with	disease	0.65
Neuropathy	transports	disease	0.65
Alzheimer	activates	disease	0.65
Neuron	activates	cell_type	0.60
Apoptosis	associated_with	pathway	0.60
Neuron	associated_with	cell_type	0.60
Neuron	encodes	cell_type	0.60
Amyloid Beta	activates	protein	0.60
Aβ	activates	protein	0.60
Myosin	associated_with	protein	0.60
Bdnf	interacts_with	protein	0.60
Ngf	interacts_with	protein	0.60
Neuron	transports	cell_type	0.60
MAO	associated_with	gene	0.60
App	associated_with	protein	0.60
TRKB	regulates	gene	0.60
TRKB	interacts_with	gene	0.60
Schwann Cell	transports	cell_type	0.60
Dynein	transports	protein	0.60
Synaptic Plasticity	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Amyloid	activates	pathway	0.60
Long-Term Potentiation	regulates	pathway	0.60
Long-Term Potentiation	associated_with	pathway	0.60
APP	regulates	gene	0.60
NTRK2	associated_with	gene	0.60
BDNF	interacts_with	gene	0.60
NGF	interacts_with	gene	0.60
Microglia	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
disease	regulates	disease	0.50
ALZHEIMER'S	regulates	concept	0.50
TRKA	interacts_with	gene	0.50
ALZHEIMER	activates	gene	0.50
AMYLOID	activates	gene	0.50
ALZHEIMER'S	activates	concept	0.50
AMYLOID BETA	activates	concept	0.50

Incoming (32)

Source	Relation	Type	Str
DYNEIN	transports	gene	0.60
ALZHEIMER	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	activates	gene	0.60
MAO	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
TRKA	regulates	gene	0.60
RET	regulates	gene	0.60
MAP1B	transports	gene	0.60
TAU	transports	gene	0.60
AMYLOID	activates	gene	0.60
TRKA	interacts_with	gene	0.60
TRKB	interacts_with	gene	0.60
APP	regulates	gene	0.60
NGF	interacts_with	gene	0.60
NTRK2	associated_with	gene	0.60
BDNF	interacts_with	gene	0.60
TRKB	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AND	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
NEURON	encodes	gene	0.60
MYELIN	transports	gene	0.60
AXON	transports	gene	0.60
ERK1/2	transports	gene	0.60
microglia	activates	cell_type	0.50
TRKB	activates	gene	0.50
late	regulates	disease	0.50
TRKB	associated_with	gene	0.50
late	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TRKC in their description or question text

No additional research found