pathway

Mismatch Repair

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Mismatch Repair: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

97Connections

1Hypotheses

0Analyses

0Outgoing

50Incoming

0Experiments

0Debates

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🔀 Pathway Info

Name	Mismatch Repair
Key Genes/Proteins	ACVR2A, AKT, APC, APOPTOSIS, ARID1A, ASH1L
Related Diseases	Als, cancer, Cancer, Carcinoma
Linked Hypotheses	1 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

PMS2 — DNA Mismatch Repair Protein PMS2

gene · 2029 words

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Pathway Diagram

graph TD
    CANCER["CANCER"] -->|"associated"| Mismatch_Repair["Mismatch Repair"]
    Cancer["Cancer"] -->|"associated"| Mismatch_Repair["Mismatch Repair"]
    P53["P53"] -->|"associated"| Mismatch_Repair["Mismatch Repair"]
    Als["Als"] -->|"treats"| Mismatch_Repair["Mismatch Repair"]
    style Mismatch_Repair fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (97)

Source	Relation	Type	Str
CANCER	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
Als	treats	disease	0.90
Cancer	therapeutic_target	disease	0.90
CANCER	therapeutic_target	gene	0.90
P53	associated_with	gene	0.90
DNA	associated_with	gene	0.80
POLE	associated_with	gene	0.80
Als	activates	disease	0.70
Als	therapeutic_target	disease	0.70
Tumor	activates	disease	0.70
DNA	causes	gene	0.70
Carcinoma	treats	disease	0.70
Cancer	treats	disease	0.70
CANCER	treats	gene	0.70
Colorectal Cancer	associated_with	disease	0.70
Gastric Cancer	associated_with	disease	0.70
CANCER	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
EP300	expressed_in	gene	0.60
Colorectal Cancer	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Tumor	expressed_in	disease	0.60
KRAS	associated_with	gene	0.60
SMAD4	associated_with	gene	0.60
APC	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
OVERVIEW	inhibits	gene	0.60
Colorectal Cancer	inhibits	disease	0.60
BAX	causes	gene	0.60
P53	causes	gene	0.60
CDH1	causes	gene	0.60
GENES	causes	gene	0.60
Tumor	causes	disease	0.60
Carcinoma	causes	disease	0.60
BAX	associated_with	gene	0.60
BRAF	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
TGFBR2	associated_with	gene	0.60
ARID1A	associated_with	gene	0.60
ACVR2A	associated_with	gene	0.60
MRE11	associated_with	gene	0.60
MSH2	associated_with	gene	0.60
MSH3	associated_with	gene	0.60
MLH1	associated_with	gene	0.60
MSH6	associated_with	gene	0.60
HDAC2	associated_with	gene	0.60
PMS2	associated_with	gene	0.60
Als	associated_with	disease	0.60
BAX	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi	0.681	neurodegeneration	CRISPR-based therapeutic approaches for

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604]	Casazza KM, Williams GM, Johengen L, Kel	bioRxiv	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning Mismatch Repair in their description or question text

No additional research found